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. 2021 Jan 19;2021(1):CD002783. doi: 10.1002/14651858.CD002783.pub5

Comparison 1. Thrombolysis versus standard anticoagulation.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Complete clot lysis (early, subgrouped by thrombolysis strategy) 8 592 Risk Ratio (M‐H, Random, 95% CI) 4.75 [1.83, 12.33]
1.1.1 Systemic 7 432 Risk Ratio (M‐H, Random, 95% CI) 3.65 [1.40, 9.56]
1.1.2 Loco‐regional 1 125 Risk Ratio (M‐H, Random, 95% CI) 10.55 [0.66, 168.79]
1.1.3 CDT 1 35 Risk Ratio (M‐H, Random, 95% CI) 21.79 [1.38, 343.26]
1.2 Complete clot lysis (intermediate, subgrouped by thrombolysis strategy) 7 654 Risk Ratio (M‐H, Random, 95% CI) 2.42 [1.42, 4.12]
1.2.1 Systemic 4 239 Risk Ratio (M‐H, Random, 95% CI) 3.80 [1.46, 9.93]
1.2.2 Loco‐regional 2 191 Risk Ratio (M‐H, Random, 95% CI) 1.75 [1.03, 2.97]
1.2.3 CDT 2 224 Risk Ratio (M‐H, Random, 95% CI) 2.52 [0.52, 12.17]
1.3 Complete clot lysis (late, subgrouped by thrombolysis strategy) 2 206 Risk Ratio (M‐H, Random, 95% CI) 3.25 [0.17, 62.63]
1.3.1 Systemic 1 34 Risk Ratio (M‐H, Random, 95% CI) 16.76 [1.03, 272.11]
1.3.2 Loco‐regional 0 0 Risk Ratio (M‐H, Random, 95% CI) Not estimable
1.3.3 CDT 1 172 Risk Ratio (M‐H, Random, 95% CI) 1.11 [0.94, 1.33]
1.4 Bleeding (early, subgrouped by thrombolysis strategy) 19 1943 Risk Ratio (M‐H, Fixed, 95% CI) 2.45 [1.58, 3.78]
1.4.1 Systemic 14 685 Risk Ratio (M‐H, Fixed, 95% CI) 1.99 [1.24, 3.19]
1.4.2 Loco‐regional 2 191 Risk Ratio (M‐H, Fixed, 95% CI) 3.07 [0.41, 23.05]
1.4.3 CDT 4 1067 Risk Ratio (M‐H, Fixed, 95% CI) 7.30 [1.67, 31.98]
1.5 PTS (intermediate, subgrouped by thrombolysis strategy) 6 1393 Risk Ratio (M‐H, Random, 95% CI) 0.78 [0.66, 0.93]
1.5.1 Systemic 2 170 Risk Ratio (M‐H, Random, 95% CI) 0.54 [0.31, 0.92]
1.5.2 Loco‐regional 2 191 Risk Ratio (M‐H, Random, 95% CI) 0.88 [0.73, 1.07]
1.5.3 CDT 3 1032 Risk Ratio (M‐H, Random, 95% CI) 0.89 [0.74, 1.05]
1.6 PTS by iliofemoral/fempop (intermediate, subgrouped by location) 6 1393 Risk Ratio (M‐H, Random, 95% CI) 0.82 [0.71, 0.94]
1.6.1 Iliofemoral DVT 4 777 Risk Ratio (M‐H, Random, 95% CI) 0.75 [0.55, 1.01]
1.6.2 Femoropopliteal DVT 1 300 Risk Ratio (M‐H, Random, 95% CI) 0.98 [0.76, 1.27]
1.6.3 Unspecified DVT 2 316 Risk Ratio (M‐H, Random, 95% CI) 0.79 [0.69, 0.92]
1.7 PTS (late, subgrouped by thrombolysis strategy) 2 211 Risk Ratio (M‐H, Fixed, 95% CI) 0.56 [0.43, 0.73]
1.7.1 Systemic 1 35 Risk Ratio (M‐H, Fixed, 95% CI) 0.35 [0.14, 0.88]
1.7.2 loco‐regional 0 0 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.7.3 CDT 1 176 Risk Ratio (M‐H, Fixed, 95% CI) 0.60 [0.45, 0.79]
1.8 Any improvement in venous patency (early) 9 421 Risk Ratio (M‐H, Random, 95% CI) 2.48 [1.35, 4.57]
1.8.1 Systemic 8 386 Risk Ratio (M‐H, Random, 95% CI) 2.18 [1.28, 3.70]
1.8.2 CDT 1 35 Risk Ratio (M‐H, Random, 95% CI) 35.05 [2.28, 539.63]
1.9 Stroke (early, subgrouped by thrombolysis strategy) 19 1943 Risk Ratio (M‐H, Fixed, 95% CI) 1.92 [0.34, 10.86]
1.9.1 Systemic 14 685 Risk Ratio (M‐H, Fixed, 95% CI) 1.92 [0.34, 10.86]
1.9.2 Loco‐regional 2 191 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.9.3 CDT 4 1067 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.10 Leg ulceration (intermediate, subgrouped by thrombolysis strategy) 5 1033 Risk Ratio (M‐H, Fixed, 95% CI) 0.76 [0.39, 1.49]
1.10.1 Systemic 2 87 Risk Ratio (M‐H, Fixed, 95% CI) 0.32 [0.01, 7.53]
1.10.2 Loco‐regional 1 66 Risk Ratio (M‐H, Fixed, 95% CI) 1.50 [0.17, 13.60]
1.10.3 CDT 2 880 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.36, 1.54]
1.11 Leg ulceration (late) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.12 Mortality (early, subgrouped by thrombolysis strategy) 10 1220 Risk Ratio (M‐H, Fixed, 95% CI) 0.76 [0.31, 1.89]
1.12.1 Systemic 8 369 Risk Ratio (M‐H, Fixed, 95% CI) 0.76 [0.31, 1.89]
1.12.2 Loco‐regional 1 125 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.12.3 CDT 2 726 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.13 Mortality (intermediate, subgrouped by thrombolysis strategy) 4 1144 Risk Ratio (M‐H, Fixed, 95% CI) 0.81 [0.39, 1.69]
1.13.1 Systemic 2 176 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.27, 3.43]
1.13.2 Loco‐regional 1 125 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.13.3 CDT 2 843 Risk Ratio (M‐H, Fixed, 95% CI) 0.76 [0.31, 1.86]
1.14 Mortality (late, subgrouped by thrombolysis strategy) 2 230 Risk Ratio (M‐H, Fixed, 95% CI) 0.61 [0.25, 1.50]
1.14.1 Systemic 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 1.33 [0.34, 5.24]
1.14.2 CDT 1 188 Risk Ratio (M‐H, Fixed, 95% CI) 0.36 [0.10, 1.30]
1.15 Recurrent DVT (intermediate, subgrouped by thrombolysis strategy) 4 1067 Risk Ratio (M‐H, Fixed, 95% CI) 1.32 [0.96, 1.83]
1.15.1 Systemic 1 35 Risk Ratio (M‐H, Fixed, 95% CI) 1.41 [0.37, 5.40]
1.15.2 Loco‐regional 0 0 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.15.3 CDT 3 1032 Risk Ratio (M‐H, Fixed, 95% CI) 1.32 [0.94, 1.84]
1.16 Recurrent DVT (late, subgrouped by thrombolysis strategy) 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.16.1 Systemic 0 0 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.16.2 CDT 1 176 Risk Ratio (M‐H, Fixed, 95% CI) 0.63 [0.34, 1.18]
1.17 Pulmonary embolism (early, subgrouped by thrombolysis strategy) 6 433 Risk Ratio (M‐H, Fixed, 95% CI) 1.01 [0.33, 3.05]
1.17.1 Systemic 5 273 Risk Ratio (M‐H, Fixed, 95% CI) 1.21 [0.36, 4.10]
1.17.2 Loco‐regional 1 125 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.17.3 CDT 1 35 Risk Ratio (M‐H, Fixed, 95% CI) 0.32 [0.01, 7.26]
1.18 Venous function (intermediate, subgrouped by thrombolysis strategy) 3 255 Risk Ratio (M‐H, Random, 95% CI) 2.18 [0.86, 5.54]
1.18.1 Systemic 1 31 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.59, 1.83]
1.18.2 Loco‐regional 0 0 Risk Ratio (M‐H, Random, 95% CI) Not estimable
1.18.3 CDT 2 224 Risk Ratio (M‐H, Random, 95% CI) 3.18 [1.41, 7.19]