Source	Search strategy	Hits retrieved
CENTRAL via CRSO	#1 MESH DESCRIPTOR Thrombosis 1312 #2 MESH DESCRIPTOR Thromboembolism 955 #3 MESH DESCRIPTOR Venous Thromboembolism 955 #4 MESH DESCRIPTOR Venous Thrombosis EXPLODE ALL TREES 2111 #5 (thrombus* or thrombopro* or thrombotic* or thrombolic* or thromboemboli* or thrombos* or embol*):TI,AB,KY 21669 #6 MESH DESCRIPTOR Pulmonary Embolism EXPLODE ALL TREES 784 #7 (PE or DVT or VTE):TI,AB,KY 5820 #8 (((vein* or ven*) near thromb*)):TI,AB,KY 7563 #9 (blood near3 clot*):TI,AB,KY 3621 #10 (pulmonary near3 clot*):TI,AB,KY 6 #11 (lung near3 clot*):TI,AB,KY 5 #12 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 28188 #13 MESH DESCRIPTOR Thrombolytic Therapy EXPLODE ALL TREES 1582 #14 MESH DESCRIPTOR Fibrinolytic Agents EXPLODE ALL TREES 11397 #15 MESH DESCRIPTOR Fibrinolysis EXPLODE ALL TREES 964 #16 MESH DESCRIPTOR Plasminogen Activators EXPLODE ALL TREES 2302 #17 (plasminogen near2 activator* ):TI,AB,KY 3945 #18 (tPA or t‐PA or rtPA or rt‐PA):TI,AB,KY 2385 #19 (thromboly* or fibrinoly* or antithrombotic or antithrombic):TI,AB,KY 9637 #20 (recanalis* or recanaliz*):TI,AB,KY 1209 #21 ((((clot* or thrombus) near3 (lyse or lysis or dissolve* or dissolution)))):TI,AB,KY 1143 #22 urokinase:TI,AB,KY 849 #23 alteplase:TI,AB,KY 887 #24 reteplase:TI,AB,KY 113 #25 tenecteplase:TI,AB,KY 184 #26 saruplase:TI,AB,KY 33 #27 anistreplase:TI,AB,KY 156 #28 monteplase:TI,AB,KY 14 #29 streptokinase:TI,AB,KY 1309 #30 staphylokinase:TI,AB,KY 18 #31 (avelizin or awelysin):TI,AB,KY 0 #32 (celiase or distreptase or Kabikinase or kabivitrum):TI,AB,KY 12 #33 (Streptase or streptodecase or apsac or Abbokinase or renokinase ):TI,AB,KY 111 #34 (Actilyse or Activase or Eminase or Retavase or Rapilysin or desmopletase or u‐pa or alfimeprase):TI,AB,KY 92 #35 streptodornase:TI,AB,KY 50 #36 (pro?urokinase or rpro?uk ):TI,AB,KY 46 #37 (lumbrokinase or duteplase or lanoteplase or pamiteplase):TI,AB,KY 45 #38 #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 20438 #39 #12 AND #38 6346 #40 01/01/2016 TO 09/04/2018:CD 229232 #41 #39 AND #40 1272	10.4.18 ‐ 1272 18.3.19 – 915 21.4.20 ‐ 1769
Clinicaltrials.gov	Venous Thrombosis OR Pulmonary Embolism OR Thromboembolism | Thrombolytic Therapy OR Fibrinolytic Agents OR Fibrinolysis OR Plasminogen Activators | Start date on or after 01/01/2016	10.4.18 ‐ 59 18.3.19 – 22 21.4.20 ‐ 31
ICTRP Search Portal	Venous Thrombosis OR Pulmonary Embolism OR Thromboembolism | Thrombolytic Therapy OR Fibrinolytic Agents OR Fibrinolysis OR Plasminogen Activators | Start date on or after 01/01/2016	10.4.18 ‐ 1 18.3.19 – 2 21.4.20 ‐ not available
MEDLINE	1 exp Venous Thrombosis/ 51052 2 exp Pulmonary Embolism/ 35949 3 (PE or DVT or VTE).ti,ab. 45773 4 ((vein* or ven*) adj thromb*).ti,ab. 60287 5 (pulmonary adj3 clot*).ti,ab. 185 6 (lung adj3 clot*).ti,ab. 46 7 or/1‐6 138870 8 exp Thrombolytic Therapy/ 22161 9 exp Fibrinolytic Agents/ 160669 10 exp FIBRINOLYSIS/ 20608 11 exp Plasminogen Activators/ 38080 12 (plasminogen adj2 activator*).ti,ab. 34984 13 (tPA or t‐PA or rtPA or rt‐PA).ti,ab. 28773 14 (thromboly* or fibrinoly* or antithrombotic or antithrombic).ti,ab. 76361 15 (recanalis* or recanaliz*).ti,ab. 11766 16 ((clot* or thrombus) adj3 (lyse or lysis or dissolve* or dissolution)).ti,ab. 3584 17 urokinase.ti,ab. 14299 18 alteplase.ti,ab. 1618 19 reteplase.ti,ab. 336 20 tenecteplase.ti,ab. 428 21 saruplase.ti,ab. 56 22 anistreplase.ti,ab. 178 23 monteplase.ti,ab. 29 24 streptokinase.ti,ab. 6869 25 staphylokinase.ti,ab. 407 26 (avelizin or awelysin).ti,ab. 19 27 (celiase or distreptase or Kabikinase or kabivitrum).ti,ab. 83 28 (Streptase or streptodecase or apsac or Abbokinase or renokinase).ti,ab. 357 29 (Actilyse or Activase or Eminase or Retavase or Rapilysin or desmopletase or u‐pa or alfimeprase).ti,ab. 2043 30 streptodornase.ti,ab. 541 31 (pro?urokinase or rpro?uk).ti,ab. 182 32 (lumbrokinase or duteplase or lanoteplase or pamiteplase).ti,ab. 124 33 or/8‐32 254354 34 7 and 33 24396 35 randomized controlled trial.pt. 457131 36 controlled clinical trial.pt. 92290 37 randomized.ab. 407065 38 placebo.ab. 187639 39 drug therapy.fs. 2005209 40 randomly.ab. 287700 41 trial.ab. 422799 42 groups.ab. 1779227 43 or/35‐42 4171773 44 exp animals/ not humans.sh. 4440009 45 43 not 44 3605151 46 34 and 45 12548 47 (2017* or 2018*).ed. 1177446 48 46 and 47 569	10.4.18 ‐ 569 18.3.19 ‐ 612 21.4.20 ‐ 644
EMBASE	1 exp vein thrombosis/ 116494 2 exp lung embolism/ 82827 3 (PE or DVT or VTE).ti,ab. 73611 4 ((vein* or ven*) adj thromb*).ti,ab. 89856 5 (pulmonary adj3 clot*).ti,ab. 286 6 (lung adj3 clot*).ti,ab. 74 7 or/1‐6 238518 8 exp Thrombolytic Therapy/ 21923 9 exp Fibrinolytic Agents/ 124797 10 exp FIBRINOLYSIS/ 70117 11 exp Plasminogen Activators/ 76700 12 (plasminogen adj2 activator*).ti,ab. 43374 13 (tPA or t‐PA or rtPA or rt‐PA).ti,ab. 38466 14 (thromboly* or fibrinoly* or antithrombotic or antithrombic).ti,ab. 105914 15 (recanalis* or recanaliz*).ti,ab. 18768 16 ((clot* or thrombus) adj3 (lyse or lysis or dissolve* or dissolution)).ti,ab. 5034 17 urokinase.ti,ab. 17500 18 alteplase.ti,ab. 2878 19 reteplase.ti,ab. 462 20 tenecteplase.ti,ab. 694 21 saruplase.ti,ab. 76 22 anistreplase.ti,ab. 207 23 monteplase.ti,ab. 50 24 streptokinase.ti,ab. 8122 25 staphylokinase.ti,ab. 486 26 (avelizin or awelysin).ti,ab. 14 27 (celiase or distreptase or Kabikinase or kabivitrum).ti,ab. 86 28 (Streptase or streptodecase or apsac or Abbokinase or renokinase).ti,ab. 406 29 (Actilyse or Activase or Eminase or Retavase or Rapilysin or desmopletase or u‐pa or alfimeprase).ti,ab. 2315 30 streptodornase.ti,ab. 488 31 (pro?urokinase or rpro?uk).ti,ab. 229 32 (lumbrokinase or duteplase or lanoteplase or pamiteplase).ti,ab. 179 33 or/8‐32 241003 34 7 and 33 30842 35 randomized controlled trial/ 497383 36 controlled clinical trial/ 459782 37 random$.ti,ab. 1290605 38 randomization/ 77656 39 intermethod comparison/ 232951 40 placebo.ti,ab. 270387 41 (compare or compared or comparison).ti. 464955 42 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab. 1722305 43 (open adj label).ti,ab. 63394 44 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. 206964 45 double blind procedure/ 148646 46 parallel group$1.ti,ab. 21541 47 (crossover or cross over).ti,ab. 91947 48 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. 278864 49 (assigned or allocated).ti,ab. 327251 50 (controlled adj7 (study or design or trial)).ti,ab. 290679 51 (volunteer or volunteers).ti,ab. 222490 52 trial.ti. 247135 53 or/35‐52 3982033 54 34 and 53 5459 55 (2017* or 2018*).dc. 2298109 56 54 and 55 646	10.4.18 ‐ 646 18.3.19 – 655 21.4.20 ‐ 639
CINAHL	S56 S54 AND S55 60 S55 EM 2017 OR EM 2018 304,727 S54 S40 AND S53 1,040 S53 S41 OR S42 OR S43 OR S44 OR S45 OR S46 OR S47 OR S48 OR S49 OR S50 OR S51 OR S52 337,202 S52 (MH "Random Assignment") 37,695 S51 (MH "Single‐Blind Studies") or (MH "Double‐Blind Studies") or (MH "Triple‐Blind Studies") 32,564 S50 MH "Crossover Design" 11,081 S49 MH "Factorial Design" 912 S48 MH "Placebos" 8,341 S47 MH "Clinical Trials" 93,020 S46 TX "multi‐centre study" OR "multi‐center study" OR "multicentre study" OR "multicenter study" OR "multi‐site study" 4,372 S45 TX crossover OR "cross‐over" 14,364 S44 AB placebo* 27,917 S43 TX random* 215,775 S42 TX trial* 246,753 S41 TX "latin square" 141 S40 S13 AND S39 3,932 S39 S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 14,556 S38 TX lumbrokinase or duteplase or lanoteplase or pamiteplase 14 S37 TX pro?urokinase or rpro?uk 0 S36 TX streptodornase 6 S35 TX Actilyse or Activase or Eminase or Retavase or Rapilysin or desmopletase or u‐pa or alfimeprase 55 S34 TX Streptase or streptodecase or apsac or Abbokinase or renokinase 25 S33 TX celiase or distreptase or Kabikinase or kabivitrum 2 S32 TX avelizin or awelysin 0 S31 TX staphylokinase 7 S30 TX streptokinase 420 S29 TX monteplase 2 S28 TX anistreplase 21 S27 TX saruplase 1 S26 TX tenecteplase 94 S25 TX reteplase 71 S24 TX alteplase 448 S23 TX urokinase 590 S22 TX (clot* or thrombus) n3 (lyse or lysis or dissolve* or dissolution) 238 S21 TX recanalis* or recanaliz* 1,104 S20 TX thromboly* or fibrinoly* or antithrombotic or antithrombic 11,686 S19 TX tPA or t‐PA or rtPA or rt‐PA 1,683 S18 TX plasminogen n2 activator* 4,608 S17 (MH "Plasminogen Activators") 367 S16 (MH "Fibrinolysis") 586 S15 (MH "Fibrinolytic Agents") 4,280 S14 (MH "Thrombolytic Therapy") 4,433 S13 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 44,352 S12 TX lung n3 clot* 21 S11 TX pulmonary n3 clot* 29 S10 TX blood n3 clot* 894 S9 TX (vein* or ven*) n thromb* 121 S8 TX PE or DVT or VTE 10,884 S7 (MH "Pulmonary Embolism") 4,686 S6 TX Pulmonary Embolism 6,325 S5 TX (thrombus* or thrombopro* or thrombotic* or thrombolic* or thromboemboli* or thrombos* or embol*): 35,783 S4 (MH "Venous Thrombosis+") 6,345 S3 (MH "Venous Thromboembolism") 3,043 S2 (MH "Thromboembolism") 3,211 S1 (MH "Thrombosis") 4,598	10.4.18 ‐ 60 18.3.19 – 119 21.4.20 ‐ 192
AMED	1 exp Thrombolytic Therapy/ 0 2 exp Fibrinolytic Agents/ 7 3 exp FIBRINOLYSIS/ 16 4 exp Plasminogen Activators/ 0 5 (plasminogen adj2 activator*).ti,ab. 45 6 (tPA or t‐PA or rtPA or rt‐PA).ti,ab. 155 7 (thromboly* or fibrinoly* or antithrombotic or antithrombic).ti,ab. 168 8 (recanalis* or recanaliz*).ti,ab. 17 9 ((clot* or thrombus) adj3 (lyse or lysis or dissolve* or dissolution)).ti,ab. 5 10 urokinase.ti,ab. 10 11 alteplase.ti,ab. 2 12 reteplase.ti,ab. 0 13 tenecteplase.ti,ab. 0 14 saruplase.ti,ab. 0 15 anistreplase.ti,ab. 0 16 monteplase.ti,ab. 0 17 streptokinase.ti,ab. 1 18 staphylokinase.ti,ab. 1 19 (avelizin or awelysin).ti,ab. 0 20 (celiase or distreptase or Kabikinase or kabivitrum).ti,ab. 0 21 (Streptase or streptodecase or apsac or Abbokinase or renokinase).ti,ab. 0 22 (Actilyse or Activase or Eminase or Retavase or Rapilysin or desmopletase or u‐pa or alfimeprase).ti,ab. 3 23 streptodornase.ti,ab. 0 24 (pro?urokinase or rpro?uk).ti,ab. 1 25 (lumbrokinase or duteplase or lanoteplase or pamiteplase).ti,ab. 4 26 or/1‐25 353 27 exp Thrombosis/ 302 28 exp Pulmonary embolism/ 53 29 (PE or DVT or VTE).ti,ab. 243 30 ((vein* or ven*) adj thromb*).ti,ab. 308 31 or/27‐30 589 32 26 and 31 39 33 ("2017" or "2018").yr. 240 34 32 and 33 1	10.4.18 ‐ 1 18.3.19 – 0 21.4.20 ‐ 1