Kakkar 1969.

Study characteristics
Methods	Allocation: random Single blind Exclusions after randomisation: 2 Losses to follow‐up: nil
Participants	Country: UK Participants: 30 Age: 18 to 77 years Sex: Male and female Inclusion criteria: venographically confirmed DVT of leg duration < 4 days Exclusion criteria: surgery < 3 days; unhealed wound; peptic ulcer; diastolic BP > 100 mmHg
Interventions	Treatment: (2 groups) streptokinase 500,000 U IV over 30 minutes, 900,000 U every 6 hours for 5 days or (Arwin) 80 U in 6 hours, then 80 units in 15 minutes, then 40 ‐ 80 U every 6 hours for 5 days Control: heparin 10,000 U over 5 minutes, then 10,000 to 15,000 U every 6 hours for 5 days Co‐treatment: oral anticoagulation commenced at end of infusions. Bed rest, leg elevation, bandages to all groups
Outcomes	1 month: mortality; PE; clot lysis; bleeding 6 to 12 months: clot lysis after partial lysis
Funding	Not reported
Declaration of interests	Not reported
Notes	1 excluded as died of PE in heparin group. 1 excluded due to bleeding in streptokinase group Included 7 patients with tibial vein thrombosis only (4 heparin, 2 streptokinase, 1 Arwin)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Description not clear
Allocation concealment (selection bias)	Unclear risk	Description not clear
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	High risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data
Selective reporting (reporting bias)	Low risk	All outcomes reported
Other bias	Low risk	None