Study	Reason for exclusion
Almroth 2009	Outcomes specified for this review were not reported or measured
Amarenco 1999	Outcomes specified for this review were not reported or measured
Amarenco 2006	Outcomes specified for this review were not reported or measured
Amarenco 2007a	Outcomes specified for this review were not reported or measured
Amarenco 2007b	Outcomes specified for this review were not reported or measured
Amarenco 2009a	Outcomes specified for this review were not reported or measured
Amarenco 2009b	Outcomes specified for this review were not reported or measured
Amarenco 2009c	Outcomes specified for this review were not reported or measured
Amarenco 2010	Outcomes specified for this review were not reported or measured
Amarenco 2014	Outcomes specified for this review were not reported or measured
Amudha 2008	Outcomes specified for this review were not reported or measured
Anonymous 1998	Outcomes specified for this review were not reported or measured
Bakker‐Arkema 1996	Outcomes specified for this review were not reported or measured
Baspinar 2016	Wrong study design; Not randomized
Berthold 2004	Outcomes specified for this review were not reported or measured
Bleda 2012	Outcomes specified for this review were not reported or measured
Bloomfield 2009	Outcomes specified for this review were not reported or measured
Braamskamp 2015	Wrong study design (non‐randomized)
Cai 2014	Wrong study design (systematic review)
Chan 2002a	Outcomes specified for this review were not reported or measured
Chan 2002b	Outcomes specified for this review were not reported or measured
Chan 2002c	Outcomes specified for this review were not reported or measured
Chan 2006	Outcomes specified for this review were not reported or measured
Chapman 2011	Outcomes specified for this review were not reported or measured
Clough 2009	Outcomes specified for this review were not reported or measured
Cohn 2009	Outcomes specified for this review were not reported or measured
Colhoun 2004	Outcomes specified for this review were not reported or measured
Crisostomo 2008	Outcomes specified for this review were not reported or measured
Cubeddu 2006	Outcomes specified for this review were not reported or measured
Cui 2006	Outcomes specified for this review were not reported or measured
Dallinga‐Thie 2006a	Outcomes specified for this review were not reported or measured
Dallinga‐Thie 2006b	Outcomes specified for this review were not reported or measured
Davidson 2002	Outcomes specified for this review were not reported or measured
Deanfield 2010	Outcomes specified for this review were not reported or measured
Diabetes 2001	Outcomes specified for this review were not reported or measured
Diepeveen 2005	Outcomes specified for this review were not reported or measured
Dogra 2007	Outcomes specified for this review were not reported or measured
Economides 2004	Outcomes specified for this review were not reported or measured
Elkawy 2014	Testosterone level was measured but not reported
EUCTR2004‐000139‐27‐SE	Outcomes specified for this review were not reported or measured
Faludi 2004	Outcomes specified for this review were not reported or measured
Ferrier 2002a	Outcomes specified for this review were not reported or measured
Ferrier 2002b	Outcomes specified for this review were not reported or measured
Fogari 2004	Outcomes specified for this review were not reported or measured
Fogari 2006	Outcomes specified for this review were not reported or measured
Freed 2002	Outcomes specified for this review were not reported or measured
Ge 2008	Outcomes specified for this review were not reported or measured
Gentile 2000	Outcomes specified for this review were not reported or measured
GlaxoSmithKline 2000	Outcomes specified for this review were not reported or measured
Glinkina 2008	Outcomes specified for this review were not reported or measured
Goldstein 2008	Outcomes specified for this review were not reported or measured
Goldstein 2009	Outcomes specified for this review were not reported or measured
Grimm 2010	Outcomes specified for this review were not reported or measured
Guo 2012	Outcomes specified for this review were not reported or measured
Hernandez 2010	Outcomes specified for this review were not reported or measured
Holman 2009	Outcomes specified for this review were not reported or measured
Holmberg 2005	Outcomes specified for this review were not reported or measured
Horwich 2011	Outcomes specified for this review were not reported or measured
Hunninghake 2001	Outcomes specified for this review were not reported or measured
Huptas 2006	Outcomes specified for this review were not reported or measured
Iavenko 2014	Outcomes specified for this review were not reported or measured
Inukai 2011	Outcomes specified for this review were not reported or measured
IRCT201208299626N1	Wrong comparator
Ishola 2017	Wrong study design (animal study)
Issa 2012	Outcomes specified for this review were not reported or measured
Jayaram 2007	Outcomes specified for this review were not reported or measured
J‐CLAS 1997	Outcomes specified for this review were not reported or measured
Joy 2008	Outcomes specified for this review were not reported or measured
JPRN‐UMIN000001114	Outcomes specified for this review were not reported or measured
Kadoglou 2011	Outcomes specified for this review were not reported or measured
Kajimoto 2009	Outcomes specified for this review were not reported or measured
Kanadasi 2006	Outcomes specified for this review were not reported or measured
Kappelle 2009	Outcomes specified for this review were not reported or measured
Kappelle 2010	Outcomes specified for this review were not reported or measured
Karam 2008	Outcomes specified for this review were not reported or measured
Kishi 2009	Outcomes specified for this review were not reported or measured
Kitas 2019	Outcomes specified for this review were not reported or measured
Knopp 2006	Outcomes specified for this review were not reported or measured
Koh 2005	Outcomes specified for this review were not reported or measured
Koh 2010	Outcomes specified for this review were not reported or measured
Kom 2007	Outcomes specified for this review were not reported or measured
Konduracka 2008	Outcomes specified for this review were not reported or measured
Krysiak 2010	Outcomes specified for this review were not reported or measured
Krysiak 2014	Wrong comparator; absence of controls
Krysiak 2016	Wrong study design (non‐randomized)
Kubler 2003	Outcomes specified for this review were not reported or measured
Kuznetsova 2010	wrong duration (14 days)
Lamon‐Fava 2007	Outcomes specified for this review were not reported or measured
Lavallee 2009	Outcomes specified for this review were not reported or measured
Lawrence 2004	Outcomes specified for this review were not reported or measured
Lewandowski 2008	Outcomes specified for this review were not reported or measured
Li 2006	Outcomes specified for this review were not reported or measured
Li 2010	Outcomes specified for this review were not reported or measured
Lins 2004	Outcomes specified for this review were not reported or measured
Liu 2009	Outcomes specified for this review were not reported or measured
Loughrey 2013	Outcomes specified for this review were not reported or measured
Macchia 2012	Outcomes specified for this review were not reported or measured
Macin 2005	Outcomes specified for this review were not reported or measured
Magen 2004	Outcomes specified for this review were not reported or measured
Maggioni 2018	Outcomes specified for this review were not reported or measured
Mal'gina 2007	Outcomes specified for this review were not reported or measured
Malekzadeh 2010	Outcomes specified for this review were not reported or measured
Manuel 2003	Outcomes specified for this review were not reported or measured
Marais 1997	Outcomes specified for this review were not reported or measured
Marchesi 2000	Outcomes specified for this review were not reported or measured
Martin 2011	Outcomes specified for this review were not reported or measured
Martin‐Ventura 2005	Outcomes specified for this review were not reported or measured
McCrindle 2003	Outcomes specified for this review were not reported or measured
Mehta 2007	Outcomes specified for this review were not reported or measured
Meng 2009	Outcomes specified for this review were not reported or measured
Messerli 2006	Outcomes specified for this review were not reported or measured
Mills 2007	Outcomes specified for this review were not reported or measured
Mishra 2005	Outcomes specified for this review were not reported or measured
Moga 2005	Outcomes specified for this review were not reported or measured
Mohler 2003	Outcomes specified for this review were not reported or measured
Moini 2012	Outcomes specified for this review were not reported or measured
Monteiro 2008	Outcomes specified for this review were not reported or measured
Muscari 2001	Outcomes specified for this review were not reported or measured
Nakamura 1997	Outcomes specified for this review were not reported or measured
Nakamura 2007	Outcomes specified for this review were not reported or measured
Naoumova 1997	Outcomes specified for this review were not reported or measured
Naoumova 1999	Outcomes specified for this review were not reported or measured
Naoumova 2003	Outcomes specified for this review were not reported or measured
Nawawi 2003	Outcomes specified for this review were not reported or measured
Nawrocki 1995	Outcomes specified for this review were not reported or measured
NCT00433823	Wrong comparator; no placebo;
NCT00522158	Wrong comparator; no placebo
NCT00603590	Outcomes specified for this review were not reported or measured
NCT01555632	Wrong setting; Study was withdrawn before participants were enrolled
NCT02497638	Wrong setting; Not started yet
NCT03784703	Outcomes specified for this review were not reported or measured
NCT04101136	Outcomes specified for this review were not reported or measured
Negi 2011	Outcomes specified for this review were not reported or measured
Neil 2010	Outcomes specified for this review were not reported or measured
Neutel 2009	Outcomes specified for this review were not reported or measured
Nicholls 2011	Outcomes specified for this review were not reported or measured
Nikitina 2009	Outcomes specified for this review were not reported or measured
Nissen 2007	Outcomes specified for this review were not reported or measured
O'Neill 2001	Outcomes specified for this review were not reported or measured
Okazaki 2004	Outcomes specified for this review were not reported or measured
Okopien 2004	Outcomes specified for this review were not reported or measured
Okopien 2005	Outcomes specified for this review were not reported or measured
Olivotti 2002	Outcomes specified for this review were not reported or measured
Olsson 2001	Outcomes specified for this review were not reported or measured
Olsson 2005	Outcomes specified for this review were not reported or measured
Olsson 2007	Outcomes specified for this review were not reported or measured
Ooi 2012	Outcomes specified for this review were not reported or measured
Oranje 2001	Outcomes specified for this review were not reported or measured
Ormiston 2004	Placebo data not reported separate from the active treatment data
Orr 2009	Outcomes specified for this review were not reported or measured
Oshima 2008	Outcomes specified for this review were not reported or measured
Ozkiris 2007	Outcomes specified for this review were not reported or measured
Packard 2007	Outcomes specified for this review were not reported or measured
Paiva 2003	Outcomes specified for this review were not reported or measured
Paiva 2005	Outcomes specified for this review were not reported or measured
Panahi 2011	Outcomes specified for this review were not reported or measured
Paolisso 2000	Outcomes specified for this review were not reported or measured
Papathanasiou 2008	Outcomes specified for this review were not reported or measured
Parini 2008	Outcomes specified for this review were not reported or measured
Parker 2011	Outcomes specified for this review were not reported or measured
Parker 2013	Outcomes specified for this review were not reported or measured
Pedro‐Botet 2001	Outcomes specified for this review were not reported or measured
Peng 2018	Outcomes specified for this review were not reported or measured
Petri 2011	Outcomes specified for this review were not reported or measured
Pfiser 2003	Outcomes specified for this review were not reported or measured
Pfizer 2003a	Outcomes specified for this review were not reported or measured
Pfizer 2003b	Outcomes specified for this review were not reported or measured
Pfizer 2003c	Outcomes specified for this review were not reported or measured
Pfizer 2004a	Outcomes specified for this review were not reported or measured
Pfizer 2004b	Outcomes specified for this review were not reported or measured
Pfizer 2004c	Outcomes specified for this review were not reported or measured
Pfizer 2005	Outcomes specified for this review were not reported or measured
Pfizer 2006a	Outcomes specified for this review were not reported or measured
Pfizer 2006b	Outcomes specified for this review were not reported or measured
Pfizer 2007	Outcomes specified for this review were not reported or measured
Pfizer 2009	Outcomes specified for this review were not reported or measured
Pfizer 2010	Outcomes specified for this review were not reported or measured
Piperi 2004	Outcomes specified for this review were not reported or measured
Plazak 2011	Outcomes specified for this review were not reported or measured
Pons‐Rejraji 2014	Wrong comparator; No control
Pontrelli 2002	Outcomes specified for this review were not reported or measured
Preston 2007	Outcomes specified for this review were not reported or measured
Raal 2000	Outcomes specified for this review were not reported or measured
Raal 2003	Wrong study design (3‐SEQUENCE CROSSOVER)
Raison 2002	Outcomes specified for this review were not reported or measured
Reiter 2005	Outcomes specified for this review were not reported or measured
Renders 2001	Outcomes specified for this review were not reported or measured
Riahi 2006	Outcomes specified for this review were not reported or measured
Rosenson 2009	Outcomes specified for this review were not reported or measured
Sadik 2010	Outcomes specified for this review were not reported or measured
Samentzas 2015	Wrong study design
Samy 2011	Outcomes specified for this review were not reported or measured
Sardo 2002	Outcomes specified for this review were not reported or measured
Sardo 2005	Outcomes specified for this review were not reported or measured
Sasmazel 2010	Outcomes specified for this review were not reported or measured
Sathyapalan 2019	Outcomes specified for this review were not reported or measured
Schaefer 2002	Outcomes specified for this review were not reported or measured
Schaefer 2004	Outcomes specified for this review were not reported or measured
Schaefer 2005	Outcomes specified for this review were not reported or measured
Schanberg 2012	Outcomes specified for this review were not reported or measured
Schneider 2004	Outcomes specified for this review were not reported or measured
Schrott 1998	Outcomes specified for this review were not reported or measured
Sdringola 2008	Outcomes specified for this review were not reported or measured
See 2003	Outcomes specified for this review were not reported or measured
Sever 2003	Outcomes specified for this review were not reported or measured
Sever 2005	Outcomes specified for this review were not reported or measured
Sever 2010	Outcomes specified for this review were not reported or measured
Sharma 2001	Outcomes specified for this review were not reported or measured
Sillesen 2007a	Outcomes specified for this review were not reported or measured
Sillesen 2007b	Outcomes specified for this review were not reported or measured
Sillesen 2008	Outcomes specified for this review were not reported or measured
Singh 2008	Outcomes specified for this review were not reported or measured
Sinski 2009	Outcomes specified for this review were not reported or measured
Soedamah‐Muthu 2003	Outcomes specified for this review were not reported or measured
Soedamah‐Muthu 2015	Outcomes specified for this review were not reported or measured
Sola 2006	Outcomes specified for this review were not reported or measured
Solem 2006	Outcomes specified for this review were not reported or measured
Sparks 2005	Outcomes specified for this review were not reported or measured
Sposito 2003	Outcomes specified for this review were not reported or measured
Stalenhoef 2005	Outcomes specified for this review were not reported or measured
Stefanadi 2009	Outcomes specified for this review were not reported or measured
Stein 2012	Outcomes specified for this review were not reported or measured
Strey 2005	Outcomes specified for this review were not reported or measured
Strey 2006	Outcomes specified for this review were not reported or measured
Suleiman 2012	Outcomes specified for this review were not reported or measured
Szramka 2007	Outcomes specified for this review were not reported or measured
Tan 2002	Outcomes specified for this review were not reported or measured
Tanaka 2001	Outcomes specified for this review were not reported or measured
Tanaka 2009	Outcomes specified for this review were not reported or measured
Taneva 2006	Outcomes specified for this review were not reported or measured
Tannous 1999	Outcomes specified for this review were not reported or measured
Tanriverdi 2005	Outcomes specified for this review were not reported or measured
Tantikosoom 2005	Outcomes specified for this review were not reported or measured
Tehrani 2010	Outcomes specified for this review were not reported or measured
Teshima 2009	Outcomes specified for this review were not reported or measured
Tousoulis 2005a	Outcomes specified for this review were not reported or measured
Tousoulis 2005b	Outcomes specified for this review were not reported or measured
Tousoulis 2005c	Outcomes specified for this review were not reported or measured
Tousoulis 2006a	Outcomes specified for this review were not reported or measured
Tousoulis 2006b	Outcomes specified for this review were not reported or measured
Tousoulis 2007	Outcomes specified for this review were not reported or measured
Tousoulis 2010	Outcomes specified for this review were not reported or measured
Tousoulis 2011	Outcomes specified for this review were not reported or measured
Tremblay 2011	Outcomes specified for this review were not reported or measured
Tsai 2008	Outcomes specified for this review were not reported or measured
Urso 2005	Outcomes specified for this review were not reported or measured
van de Ree 2003	Outcomes specified for this review were not reported or measured
Van De Ree 2003	Outcomes specified for this review were not reported or measured
van der Harst 2005	Outcomes specified for this review were not reported or measured
van Doorn 2006	Outcomes specified for this review were not reported or measured
van Hoek 2009	Outcomes specified for this review were not reported or measured
Van J 2002	Outcomes specified for this review were not reported or measured
Vansant 2001	Outcomes specified for this review were not reported or measured
van Venrooij 2002	Outcomes specified for this review were not reported or measured
van Venrooij 2003	Outcomes specified for this review were not reported or measured
Vernaglione 2004	Outcomes specified for this review were not reported or measured
von Eynatten 2009	Outcomes specified for this review were not reported or measured
Vrtovec 2005	Outcomes specified for this review were not reported or measured
Wang 2001	Outcomes specified for this review were not reported or measured
Wanner 2005	Outcomes specified for this review were not reported or measured
Wassmann 2004	Outcomes specified for this review were not reported or measured
Waters 2000	Outcomes specified for this review were not reported or measured
Watts 2003a	Outcomes specified for this review were not reported or measured
Watts 2003b	Outcomes specified for this review were not reported or measured
Williams 2009	Outcomes specified for this review were not reported or measured
Wissing 2006	Outcomes specified for this review were not reported or measured
Wojnicz 2006	Outcomes specified for this review were not reported or measured
Wu 2007	Outcomes specified for this review were not reported or measured
Xia 2009	Outcomes specified for this review were not reported or measured
Xie 2010	Outcomes specified for this review were not reported or measured
Yamada 2007	Outcomes specified for this review were not reported or measured
Yamada 2009	Outcomes specified for this review were not reported or measured
Yokoyama 2005	Outcomes specified for this review were not reported or measured
Young 2008	Outcomes specified for this review were not reported or measured
Zeng 2012	Outcomes specified for this review were not reported or measured
Zhang 2009a	Outcomes specified for this review were not reported or measured
Zhang 2009b	Outcomes specified for this review were not reported or measured
Zheng 2019	Outcomes specified for this review were not reported or measured