| 1.1 Cumulative live birth rate |
8 |
4712 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.08 [0.95, 1.22] |
| 1.1.1 Live birth rate: cumulatively for cleavage stage transfer |
3 |
2415 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.09 [0.93, 1.29] |
| 1.1.2 Live birth rate: cumulatively for blastocyst stage transfer |
5 |
2297 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.06 [0.88, 1.27] |
| 1.2 Ovarian hyperstimulation syndrome (OHSS) |
6 |
|
Peto Odds Ratio (Peto, Fixed, 95% CI) |
Subtotals only |
| 1.2.1 Per cycle with ovarian hyperstimulation |
6 |
4478 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.26 [0.17, 0.39] |
| 1.3 Cumulative ongoing pregnancy rate |
4 |
1245 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.95 [0.75, 1.19] |
| 1.3.1 Ongoing pregnancy rate: cumulatively for cleavage stage transfer |
1 |
782 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.78, 1.37] |
| 1.3.2 Ongoing pregnancy rate: cumulatively for blastocyst stage transfer |
3 |
463 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.80 [0.54, 1.18] |
| 1.4 Cumulative clinical pregnancy rate |
4 |
1320 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.92 [0.72, 1.16] |
| 1.4.1 Clinical pregnancy rate: cumulatively for cleavage stage transfer |
2 |
907 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.00 [0.76, 1.32] |
| 1.4.2 Clinical pregnancy rate: cumulatively for blastocyst stage transfer |
2 |
413 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.70 [0.44, 1.13] |
| 1.5 Ectopic pregnancy |
6 |
|
Peto Odds Ratio (Peto, Fixed, 95% CI) |
Subtotals only |
| 1.5.1 Ectopic pregnancy: cumulatively |
2 |
986 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.61 [0.31, 1.22] |
| 1.5.2 Ectopic pregnancy: after first embryo transfer |
5 |
4274 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.64 [0.39, 1.06] |
| 1.6 Miscarriage |
8 |
|
Peto Odds Ratio (Peto, Fixed, 95% CI) |
Subtotals only |
| 1.6.1 Miscarriage rate: cumulatively |
2 |
986 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.06 [0.72, 1.55] |
| 1.6.2 Miscarriage rate: after first embryo transfer |
8 |
4569 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.90 [0.76, 1.07] |
| 1.7 Multiple pregnancy |
5 |
5252 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.10 [0.92, 1.31] |
| 1.7.1 Multiple pregnancy rate: cumulatively |
2 |
986 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.88 [0.61, 1.25] |
| 1.7.2 Multiple pregnancy rate: after first embryo transfer |
5 |
4266 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.18 [0.96, 1.45] |
| 1.8 Gestational diabetes mellitus |
3 |
4722 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.26 [0.92, 1.71] |
| 1.8.1 Gestational diabetes mellitus: cumulatively |
1 |
782 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.83 [0.36, 1.94] |
| 1.8.2 Gestational diabetes mellitus: after first embryo transfer |
3 |
3940 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.34 [0.96, 1.86] |
| 1.9 Hypertensive disorders of pregnancy |
3 |
4722 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.80 [1.23, 2.64] |
| 1.9.1 Hypertensive disorders of pregnancy: cumulatively |
1 |
782 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.70 [0.27, 1.82] |
| 1.9.2 Hypertensive disorders of pregnancy: after first embryo transfer |
3 |
3940 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
2.15 [1.42, 3.25] |
| 1.10 Preterm delivery (< 37 weeks of gestational age) |
4 |
4926 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.00 [0.80, 1.25] |
| 1.10.1 Preterm delivery (< 37 weeks of gestational age): cumulatively |
2 |
986 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.62 [0.39, 0.99] |
| 1.10.2 Preterm delivery (< 37 weeks of gestational age): after first embryo transfer |
3 |
3940 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.15 [0.89, 1.50] |
| 1.11 Perinatal and neonatal death |
2 |
3072 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.18 [0.40, 3.51] |
| 1.11.1 Perinatal and neonatal death: cumulatively |
1 |
782 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.13 [0.01, 1.30] |
| 1.11.2 Perinatal and neonatal death: after first embryo transfer |
2 |
2290 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
2.27 [0.65, 7.84] |
| 1.12 Neonatal hospitalisation (> 3 days or neonatal intensive care unit admission) |
3 |
4722 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.35 [1.06, 1.72] |
| 1.12.1 Neonatal hospitalisation (> 3 days or neonatal intensive care unit admission): cumulatively |
1 |
782 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.00 [0.29, 3.48] |
| 1.12.2 Neonatal hospitalisation (> 3 days or neonatal intensive care unit admission): after first embryo transfer |
3 |
3940 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.37 [1.07, 1.75] |
| 1.13 Large for gestational age (birth weight > 90th percentile) |
3 |
4722 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.96 [1.52, 2.53] |
| 1.13.1 Large for gestational age (birth weight > 90th percentile): cumulatively |
1 |
782 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.97 [0.63, 6.15] |
| 1.13.2 Large for gestational age (birth weight > 90th percentile): after first embryo transfer |
3 |
3940 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.96 [1.51, 2.55] |
| 1.14 Small for gestational age (birth weight < 10th percentile) |
3 |
4722 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.77 [0.61, 0.97] |
| 1.14.1 Small for gestational age (birth weight < 10th percentile): cumulatively |
1 |
782 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.36 [0.16, 0.80] |
| 1.14.2 Small for gestational age (birth weight < 10th percentile): after first embryo transfer |
3 |
3940 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.82 [0.65, 1.05] |
| 1.15 Congenital abnormalities per live‐born children |
3 |
1789 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.08 [0.65, 1.78] |
| 1.16 Birth weight of babies born |
5 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.16.1 Birth weight of singletons |
5 |
1607 |
Mean Difference (IV, Fixed, 95% CI) |
127.44 [77.08, 177.80] |
| 1.16.2 Birth weight of multiples |
4 |
804 |
Mean Difference (IV, Fixed, 95% CI) |
49.46 [‐21.15, 120.08] |
