Comparison 1. Main analysis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 All‐cause mortality	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1.1 Adults	1	173	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.57, 1.37]
1.1.2 Pediatric	1	184	Risk Ratio (M‐H, Fixed, 95% CI)	1.47 [0.85, 2.53]
1.2 Serious adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.2.1 Pediatric	1	184	Risk Ratio (M‐H, Fixed, 95% CI)	1.25 [0.35, 4.51]
1.3 Liver transplant at 21 days	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.3.1 Adults	1	173	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.49, 1.06]
1.3.2 Pediatric	1	184	Risk Ratio (M‐H, Fixed, 95% CI)	1.23 [0.84, 1.81]
1.4 Liver transplant at 1 year	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.4.1 Pediatric	1	184	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.89, 1.84]
1.5 Non‐serious adverse events	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.5.1 Adults	1	173	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.71, 1.45]
1.5.2 Pediatric	1	184	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.65, 2.16]