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. 2021 Mar 31;2021(3):CD012250. doi: 10.1002/14651858.CD012250.pub2
Author Number of included RCTs (number of participants) Devices used Outcomes reported (compared to surgical circumcision technique)
Adverse events Operative time Postoperative time pain during first 24 hours Postoperative appearance or satisfaction
Cao 2015 8 (3314) SR
vs
standard surgical circumcision
RR 0.54, 95% CI 0.39 to 0.74; P < 0.001 MD –17.44, 95% CI –21.61 to –13.27; P < 0.001 Intraoperative pain score: MD –3.13, 95% CI 3.79 to 2.47; P < 0.001 RR 1.29, 95% CI 1.07 to 1.56; P = 0.007
Fan 2016 10 (4649)
(pair‐wise and network meta‐analysis conducted)
CDD such as DCSD and Unicirc
vs
ISD, e.g. SR and PrePex
vs
surgical circumcision technique
CDD: RR 1.00, 97.5% CI 0.30 to 3.39
ISD: RR 0.77, 97.5% CI 0.47 to 1.26
CDD: SMD –4.33, 97.5% CI –6.43 to –2.23
ISD: SMD –5.72, 97.5% CI –7.11 to –4.33
CDD: SMD –1.38, 97.5% CI –2.28 to –0.48
ISD: SMD –0.95, 97.5% CI –3.09 to 1.19
(no specific time point mentioned for measuring postoperative pain)
CDD: RR 1.12, 97.5% CI 0.96 to 1.30
ISD: RR 1.17, 97.5% CI 1.02 to 1.35
Huang 2017 18 (6179)
(pair‐wise and network meta‐analyses conducted)
DCSD
vs
SR
vs
surgical circumcision technique
DCSD: OR 0.37, 95% CrI 0.19 to 0.71
SR: OR 1.27, 95% CrI 0.71 to 2.31
DCSD: SMD –20.60, 95% CrI –23.38 to –17.83
SR: SMD –19.14, 95% CrI –21.86 to –16.50
DCSD: SMD –2.01, 95% CrI –4.57 to 0.60
SR: SMD –1.64, 95% CrI –3.77 to 0.54
DCSD: OR 11.42, 95% CrI 3.60 to 37.68
SR: OR 3.85, 95% CrI 1.29 to 12.79
Huo 2017 9 (1898) DCSD
vs
surgical circumcision technique
DCSD: OR 0.60, 95% CI 0.41 to 0.87; P = 0.008 DCSD: SMD –21.44, 95% CI –25.08 to –17.79; P < 0.00001 DCSD: SMD –2.36, 95% CI –2.50 to –2.22; P < 0.00001 DCSD: OR 8.77, 95% CI 5.90 to 13.02; P < 0.00001
CDD: circular disposable devices; CI: confidence interval; CrI: credible interval; DCSD: disposable circumcision suture device; ISD: in situ device; MD: mean difference; OR: odds ratio; RCT: randomized controlled trial; RR: risk ratio; SMD: standardized mean difference; SR: Shang Ring.