Author | Number of included RCTs (number of participants) | Devices used | Outcomes reported (compared to surgical circumcision technique) | |||
Adverse events | Operative time | Postoperative time pain during first 24 hours | Postoperative appearance or satisfaction | |||
Cao 2015 | 8 (3314) | SR vs standard surgical circumcision |
RR 0.54, 95% CI 0.39 to 0.74; P < 0.001 | MD –17.44, 95% CI –21.61 to –13.27; P < 0.001 | Intraoperative pain score: MD –3.13, 95% CI 3.79 to 2.47; P < 0.001 | RR 1.29, 95% CI 1.07 to 1.56; P = 0.007 |
Fan 2016 | 10 (4649) (pair‐wise and network meta‐analysis conducted) |
CDD such as DCSD and Unicirc vs ISD, e.g. SR and PrePex vs surgical circumcision technique |
CDD: RR 1.00, 97.5% CI 0.30 to 3.39 ISD: RR 0.77, 97.5% CI 0.47 to 1.26 |
CDD: SMD –4.33, 97.5% CI –6.43 to –2.23 ISD: SMD –5.72, 97.5% CI –7.11 to –4.33 |
CDD: SMD –1.38, 97.5% CI –2.28 to –0.48 ISD: SMD –0.95, 97.5% CI –3.09 to 1.19 (no specific time point mentioned for measuring postoperative pain) |
CDD: RR 1.12, 97.5% CI 0.96 to 1.30 ISD: RR 1.17, 97.5% CI 1.02 to 1.35 |
Huang 2017 | 18 (6179) (pair‐wise and network meta‐analyses conducted) |
DCSD vs SR vs surgical circumcision technique |
DCSD: OR 0.37, 95% CrI 0.19 to 0.71 SR: OR 1.27, 95% CrI 0.71 to 2.31 |
DCSD: SMD –20.60, 95% CrI –23.38 to –17.83 SR: SMD –19.14, 95% CrI –21.86 to –16.50 |
DCSD: SMD –2.01, 95% CrI –4.57 to 0.60 SR: SMD –1.64, 95% CrI –3.77 to 0.54 |
DCSD: OR 11.42, 95% CrI 3.60 to 37.68 SR: OR 3.85, 95% CrI 1.29 to 12.79 |
Huo 2017 | 9 (1898) | DCSD vs surgical circumcision technique |
DCSD: OR 0.60, 95% CI 0.41 to 0.87; P = 0.008 | DCSD: SMD –21.44, 95% CI –25.08 to –17.79; P < 0.00001 | DCSD: SMD –2.36, 95% CI –2.50 to –2.22; P < 0.00001 | DCSD: OR 8.77, 95% CI 5.90 to 13.02; P < 0.00001 |
CDD: circular disposable devices; CI: confidence interval; CrI: credible interval; DCSD: disposable circumcision suture device; ISD: in situ device; MD: mean difference; OR: odds ratio; RCT: randomized controlled trial; RR: risk ratio; SMD: standardized mean difference; SR: Shang Ring. |