Skip to main content
. 2020 Oct 29;2020(10):CD001892. doi: 10.1002/14651858.CD001892.pub5

Teplan 1998.

Study characteristics
Methods
  • Study design: parallel RCT

  • Duration of study: not reported

  • Study follow‐up period: 3 years

Participants
  • Country: Czech Republic

  • Setting: outpatient

  • Patients with CKD

  • Number: very low protein diet (35); low protein diet (38); restricted protein diet (32)

  • Age range: 26 to 78 years

  • Sex (M/F): 50/55

  • Exclusion criteria: diabetic kidney disease; failure to co‐operate; compliance ≤ 50%; severe associated disease (cancer, severe forms of atherosclerosis, chronic infection, immunosuppression)

Interventions Very low protein diet
  • Prescribed protein diet: 0.4 g/kg/day + keto amino acids


Low protein diet
  • Prescribed protein diet: 0.6 g/kg/day


Restricted protein diet
  • Prescribed protein diet: 0.8 to 1.0 g/kg/day


Co‐interventions
  • Hypertension treated with low dose ACEi and CCB

Outcomes
  • Metabolic status

  • Kidney function (SCr, urea, proteinuria)

Notes
  • Abstract‐only publication; no full text publication identified

  • Funding source: not reported

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Study was described as randomised, method of randomisation was not reported
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgement
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Insufficient information to permit judgement
Blinding of outcome assessment (detection bias): End or change in GFR
End of change in GFR Unclear risk Insufficient information to permit judgement
Blinding of outcome assessment (detection bias): Need to start dialysis
Need to start dialysis Unclear risk Insufficient information to permit judgement
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Insufficient information to permit judgement
Selective reporting (reporting bias) High risk No extractable data; no full‐text publication identified
Other bias Unclear risk Insufficient information to permit judgement