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. 2021 Apr 1;58:42–49. doi: 10.1016/j.breast.2021.03.012

Table 3.

Clinical endpoints, by Cycle, ITT Analysis.


Ciprofloxacin
G-CSF
Cycle 1 2 3 4 1 2 3 4
n (%) 221 203 199 196 222 214 211 202
Febrile Neutropenia 23 (10.4) 17 (8.4) 9 (4.5) 5 (2.6) 10 (4.5) 8 (3.7) 4 (1.9) 3 (1.5)
Treatment-related Hospitalisation 25 (11.3) 10 (4.9) 4 (2.0) 5 (2.6) 15 (6.8) 8 (3.7) 7 (3.3) 2 (1.0)
Chemotherapy dose reduction 0 19 (9.4) 12 (6.0) 6 (3.1) 0 18 (8.4) 12 (5.7) 9 (4.5)
Chemotherapy discontinuation 18 (8.1) 4 (2.0) 3 (1.5) 8 (4.1) 8 (3.6) 3 (1.4) 5 (2.4) 9 (4.5)
Chemotherapy dose delay 0 9 (4.4) 5 (2.5) 2 (1.0) 0 5 (2.3) 9 (4.3) 6 (3.0)
Microinfection 5 (2.3) 5 (2.5) 2 (1.0) 1 (0.5) 6 (2.7) 6 (2.8) 1 (0.5) 1 (0.5)