35.

Forest plot of splitting direct and indirect evidence for outcome skeletal‐related event: pathological fractures. In addition to the confidence interval for the network estimator, a prediction interval is shown.

Local approach to check inconsistency—comparison of direct and indirect estimate for closed loops. As presented in Figure 32, there is one closed loop in the network (zoledronic acid—clodronate—no treatment/placebo). There is no significant difference between direct and indirect estimate (P value of test for disagreement: P = 0.958).