71.

Forest plot of splitting direct and indirect evidence for the secondary outcome adverse event: hypocalcemia. In addition to the confidence interval for the network estimator, a prediction interval is shown. Local approach to check inconsistency—comparison of direct and indirect estimate for closed loops. As presented in Figure 67, there is one closed loop in the network (zoledronic acid—clodronate—no treatment/placebo). There is no significant difference between direct and indirect estimate (P value of test for disagreement: P = 0.20).