Gannon 1991.
Study characteristics | ||
Methods | Randomisation by sealed envelope Single‐centre, parallel‐group, no blinding Setting: Royal Berkshire Hospital in Reading, UK Number of women randomly assigned: 54 Number of withdrawals: 3 (1 from the resection group who wanted hysterectomy, 1 from the hysterectomy group who wanted resection, and 1 from the hysterectomy group who postponed surgery and was treated elsewhere) Power calculation and intention‐to‐treat analysis not reported |
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Participants | Women with median age 40 years awaiting abdominal hysterectomy for menorrhagia Exclusion criteria: leiomyomata; endometrial or cervical neoplasia; concomitant ovarian pathology, PID or endometriosis |
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Interventions | Treatment 1: endometrial resection (TCRE): 25 women Treatment 2: abdominal hysterectomy: 26 women Duration: mean 12 months' follow‐up Procedures performed by 'experienced surgeons on routine operating lists' Endometrial resection group given an intramuscular injection of medroxyprogesterone acetate 150 mg 4–6 weeks before surgery to reduce endometrial thickness. |
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Outcomes |
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Notes | Author contacted but no reply received. Source of funding: not reported. No information stated regarding trial registration |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomisation sequence not described. |
Allocation concealment (selection bias) | Unclear risk | Sealed envelope but no other safeguards described. |
Blinding (performance bias and detection bias) All outcomes | High risk | Not feasible for a comparison of surgical techniques. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Dropouts minimal and not likely to cause bias. |
Selective reporting (reporting bias) | Unclear risk | No prior protocol identified. |
Other bias | Low risk | Groups appeared balanced at baseline, although very few parameters examined. |