Item | Yes/no | Comment |
I. Is the study population clearly described? | Yes | Clinical characteristics of participants and withdrawals stated and described explicitly. |
2. Are competing alternatives clearly described? | No | Usual care, authors state community‐based care determined by local policy and practices, no further information on timing, duration or frequency |
3. Is a well‐defined research question posed in answerable form? | Yes | Research question for economic evaluation stated: "Is SCC care under the new system of care cost‐effective compared with SCC care according to usual practice, from either a health and social care perspective or a societal perspective?" |
4. Is the economic study design appropriate to the stated objective? | Yes | Cluster randomised trial, using cost‐effectiveness analysis and cost‐utility analysis. |
5. Is the chosen time horizon appropriate to include relevant costs and consequences? | Yes | Evaluated cost‐effectiveness at 6 months (primary endpoint) though also explored outcomes at 12‐month time point, which would have allowed additional adequate time for all relevant costs and benefits to become apparent. |
6. Is the actual perspective chosen appropriate? | Yes | 2 perspectives taken for patients and carers: health and social care cost perspective and a societal perspective. |
7. Are all important and relevant costs for each alternative identified? | Yes | Unit costs of residential and nursing home stay, inpatient services, outpatient services, value of carer time, SCC time and stroke multidisciplinary meeting, total health and social care costs. |
8. Are all costs measured appropriately in physical units? | Yes | A Client Service Receipt Inventory specifically adapted for this study was used, based on versions used successfully in previous large stroke rehabilitation trials. |
9. Are costs valued appropriately? | Yes | Opportunity costs considered in unit costs in the form of wage cost and leisure time cost. |
10. Are all important and relevant outcomes for each alternative identified? | Yes | Economic evaluation was based on individual‐level data collected within the trial. It assessed cost‐effectiveness based on the GHQ‐12 and cost– utility based on quality‐adjusted life‐years (QALYs) derived from the EQ‐5D. |
11. Are all outcomes measured appropriately? | Yes | GHQ‐12 and EQ‐5D validated measures. |
12. Are outcomes valued appropriately? | Yes | Indirect utility assessment using the EQ‐5D, utility weights were taken from a UK population survey. |
13. Is an incremental analysis of costs and outcomes of alternatives performed? | No | No suggested between‐group differences for cost and outcomes, ICERs not calculated. |
14. Are all future costs and outcomes discounted appropriately? | Yes | Time horizon limited to 12 months, discounting only necessary if time horizon > 1 year. |
15. Are all important variables, whose values are uncertain, appropriately subjected to sensitivity analysis? | Yes | Sensitivity analysis conducted imputing missing health and social care costs and QALYs at 6 months. |
16. Do the conclusions follow from the data reported? | Yes | Authors reported no evidence of cost effectiveness in line with economic analysis results. |
17. Does the study discuss the generalisability of the results to other settings and patient/client groups? | Yes | Authors stated good generalisability: "The range of disparate geographical regions ensured a good representation of different healthcare settings optimizing generalizability." Authors also discussed keeping eligibility criteria to a minimum, to ensure the stroke patient population was representative of usual referrals to SCCs including patients with language and cognitive impairments. |
18. Does the article indicate that there is no potential conflict of interest of study researcher(s) and funder(s)? | Yes | Authors stated in 'Sources of Funding' that this is independent research. |
19. Are ethical and distributional issues discussed appropriately? | No | Socioeconomic status of patients/carers not discussed in detail, education level and main employment before stroke reported for stroke participants. |