Table 4.
Age, sex and BMI-adjusted linear mixed regression estimates (standardized β coefficients) between circulating liver enzymes (ALT, AST, GGT), anthropometrics and cardiometabolic risk factors.
| ALTa (U/l) | ASTa (U/l) | GGTa (U/l) | |
|---|---|---|---|
| β | β | β | |
| Anthropometrics | |||
| Waist, cm | 0.42** | 0.37* | 0.22 |
| Cardiometabolic biomarkers | |||
| Systolic blood pressure, mmHg | 0.20* | 0.14 | 0.19* |
| Diastolic blood pressure, mmHg | 0.22** | 0.23** | 0.23** |
| Heart rate, bpm | 0.17* | 0.25** | 0.23** |
| Blood pressure medication | -0.07 | -0.05 | -0.07 |
| Cholesterol medication | -0.10 | -0.001 | -0.01 |
| Glucose, mmol/l | 0.19* | 0.10 | 0.08 |
| Insulin, mU/l | 0.41*** | 0.36*** | 0.20* |
| HOMA-IR | 0.42*** | 0.36*** | 0.21* |
| Triglycerides, mmol/l | 0.15 | 0.04 | 0.15 |
| Cholesterol, mmol/l | 0.003 | -0.007 | 0.08 |
| HDL, mmol/l | -0.16 | -0.15 | -0.10 |
| LDL, mmol/l | 0.001 | 0.05 | 0.06 |
| HbA1c, mmol/mol | 0.23** | 0.17* | 0.03 |
Significant p-values; * < 0.05, ** < 0.01, *** < 0.001
ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyltransferase; HOMA-IR, homeostatic model assessment for insulin resistance. a = log10 transformed variables.