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. 2021 Apr 20;12:654569. doi: 10.3389/fendo.2021.654569

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Copyright © 2021 López-Márquez, Carrasco-López, Fernández-Méndez and Santisteban

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of the promoter regions of the main thyroid differentiation genes. Schematic representation of the main transcription factor binding sites found in the promoter regions of the genes: Thyroglobulin (Tg), Thyroid peroxidase (Tpo), TSH receptor (Tshr) and Sodium/iodide symporter (Nis, Slc5a5). In the case of Slc5a5, the proximal promoter, and the Nis Upstream Enhancer (NUE) are separately indicated. Black arrows represent the transcriptional initiation site of each promoter and numbers define its position. The TATA box is indicated as well as the binding sites for transcription factors: Nkx2-1, Foxe1, Pax8, CREB, CRE-L (CRE-Like) and IRE (Insulin Respose Element).