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. 2021 Apr 23;6(3):100125. doi: 10.1016/j.esmoop.2021.100125

Figure 2.

Figure 2

Impact of exogenous factor on 5-FU metabolism. Leucovorin (LV) treatment and uridine metabolism are presented in two mechanisms of 5-FU action. The FdUMP, TS, and 5,10, methylene-THF ternary complex is stabilised by the administration of LV (A). Administration of uridine lowers UMP catabolisation; higher amounts of UMP, UDP, and UTP facilitate UTP on FUTP RNA incorporation (B). FdUMP, 5-fluoro-deoxyuridine monophosphate; FUTP, fluorouridine triphosphate; TS, thymidylate synthase; UMP, uridine monophosphate; UDP, uridine diphosphate; UTP, uridine triphosphate.