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. 2021 Mar 26;296:100597. doi: 10.1016/j.jbc.2021.100597

Figure 6.

Figure 6

In vivo effect of C77.A, the scheme of the experimental procedure. B, IL-18 concentration in the frontal cortex of mice intraperitoneally administrated 50 mg/kg of C77 or vehicle (DMSO) 2 h before IP administration of 15 mg/kg of LPS or vehicle (PBS). C, IL-1β quantification in different brain regions of mice treated with vehicle, LPS, or C77+LPS. (Animals per group: vehicle, n = 5; LPS, n = 5; C77-LPS n = 4). D, RNA expression levels of inflammatory genes in the brain of mice treated with vehicle (DMSO), or C77 before PBS, or LPS IP injection. All treatment groups, n = 5. The data shown correspond to average values of biological replicates (ran in technical duplicates) ± SEM. Statistical significances are referred to control samples. Significance levels, as calculated by one-way ANOVA, are indicated as ∗p ≤ 0.05, ¥p ≤ 0.01, §p ≤ 0.001, and ¶p ≤ 0.0001. IP, intraperitoneal.