Table 3.
Hospital admissions according to age and dose intensity
| Characteristic | Age 70-79 y | Age ≥80 y | All patients (N = 690) | ||
|---|---|---|---|---|---|
| IDI ≥80% (n = 299) | IDI <80% (n = 153) | IDI ≥80% (n = 35) | IDI <80% (n = 203) | ||
| Cycles of R-CHOP* | |||||
| Total | 1674 | 802 | 171 | 1030 | 3677 |
| Mean | 5.6 | 5.2 | 4.9 | 5.1 | 5.3 |
| Admissions per cycle | |||||
| Total (%)* | 335 (20.0) | 184 (22.9) | 48 (28.1) | 230 (22.3) | 797 (21.7) |
| Mean | 22.1 | 29.2 | 34.6 | 30.8 | 26.9 |
| Admissions* | |||||
| Median (range) | 1 (0-9) | 1 (0-6) | 1 (0-7) | 1 (0-9) | 1 (0-9) |
| Mean | 1.1 | 1.2 | 1.4 | 1.1 | 1.2 |
| Admissions during chemotherapy for infection | |||||
| Yes | 98 (33.0) | 40 (26.1) | 11 (32.4) | 43 (21.3) | 192 (28.0) |
| No | 199 (67.0) | 113 (73.9) | 23 (67.6) | 159 (78.7) | 494 (72.0) |
| Missing | 2 | 0 | 1 | 1 | 4 |
| Total cumulative inpatient days | |||||
| Median (range) | 2 (0-146) | 5 (0-120) | 5 (0-56) | 2 (0-92) | 2 (0-146) |
| Mean | 8.1 | 13.3 | 10.1 | 11.9 | 10.5 |
| All-cause admissions | |||||
| Yes | 164 (55.0) | 97 (63.4) | 20 (57.1) | 116 (57.1) | 397 (57.6) |
| No | 135 (45.3) | 56 (36.6) | 15 (42.9) | 87 (42.9) | 293 (42.5) |
| Missing | 0 | 0 | 0 | 0 | 0 |
| Cycle 1 of R-CHOP received as inpatient | |||||
| Yes | 73 (24.5) | 67 (43.8) | 9 (26.5) | 72 (35.6) | 221 (32.2) |
| No | 225 (75.5) | 86 (56.2) | 25 (73.5) | 130 (64.4) | 466 (67.8) |
| Missing | 1 | 0 | 1 | 1 | 3 |
| Common causes of admission (mean rate % per cycle)* | |||||
| Neutropenic fever | 118 (7.9) | 29 (3.9) | 10 (7.4) | 23 (2.9) | 180 (5.5) |
| Non-neutropenic infection or fever | 59 (3.8) | 32 (5.8) | 9 (5.2) | 47 (6.0) | 147 (4.9) |
| Abdominal pain or distension | 12 (0.7) | 6 (1.2) | 2 (1.0) | 2 (0.2) | 22 (0.7) |
| Electrolyte or metabolic abnormality | 5 (0.3) | 8 (1.2) | 0 | 3 (0.2) | 16 (0.5) |
Data are presented as n (%) unless otherwise specified.
*
Excluding patients with unknown >0 infection-related admissions.