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. 2021 Apr 6;11:657665. doi: 10.3389/fonc.2021.657665

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Copyright © 2021 Wang, Yang, Feng, Zhu, Qiu, Hu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of apigenin on the growth, colony formation, cell cycle progression, and apoptosis rate of Huh7 and Hep3B cells in intro. (A, B) Changes in cell viability as determined by the CCK-8 assay. (C) Colony formation. (D) Cell cycle distribution. (E) Apoptosis analysis by Annexin-V/PI staining. (F) Transwell invasion assay. ^* P < 0.05, ^** P < 0.01, indicating significant differences in comparison to the control treatment (0.1% DMSO) group. Data are shown as mean ± SD from three independent experiments.