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. 2021 Apr 6;11:657665. doi: 10.3389/fonc.2021.657665

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Copyright © 2021 Wang, Yang, Feng, Zhu, Qiu, Hu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of apigenin on the tumorigenicity of Huh7 xenograft in nude mice. (A) Tumor growth curves of Huh7 cells treated with apigenin (25 mg/kg/day) or vehicle control (0.1% DMSO). (B) Tumor masses of each treatment group. (C) Photographs of resected tumors (n = 6) from each treatment group. (D) Representative tumor sections stained with H&E, anti-Bax, anti-Bcl2, anti-Ki67 antibodies and Tunel assay kit. Original magnification: ×400. ^** P < 0.01 in comparison to the control treatment (0.1% DMSO) group.