Figure 8.

Adipose-specific overexpression of Cbr1 worsened metabolic status on a chow diet but did not exacerbate the effects of high-fat feeding. (A) Glucose tolerance tests (GTT) in the male R26-Cbr1^Fl and R26-Cbr1^Adpq mice on a chow diet and after high-fat feeding (n = 5–7 mice/group). (B) Area under the curve for GTT in the male mice. (C) Fasting plasma glucose concentrations in the male R26-Cbr1^Fl and R26-Cbr1^Adpq mice (n = 6–10 mice/group). (D) Glucose tolerance tests (GTTs) in the female R26-Cbr1^Fl and R26-Cbr1^Adpq mice on a chow diet and after high-fat feeding (n = 6–9 mice/group). (E) Area under the curve for GTTs in the female mice. (F) Fasting plasma glucose concentrations in the female R26-Cbr1^Fl and R26-Cbr1^Adpq mice (n = 6–8 mice/group). (G) The mRNA expression of glucocorticoid receptor (GR), mineralocorticoid receptor (MR), GR-responsive gene patatin-like phospholipase domain containing 2 (Pnpla2) that encodes adipose triglyceride lipase (Atgl), Tsc22d3 that encodes glucocorticoid-induced leucine zipper protein (Gilz), period 1 (Per1), tumour necrosis factor α (Tnfα), and MR-responsive gene prostaglandin D2 synthase (Ptdgs) in the subcutaneous adipose tissue of the male R26-Cbr1^Fl and R26-Cbr1^Adpq mice on a chow diet (n = 6–7/group). Data are mean ± SEM. Statistical significance was assessed by the Mann–Whitney U test and ANOVA. ∗p < 0.05 and ∗∗p < 0.01.