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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Cell Rep. 2021 Apr 6;35(1):108954. doi: 10.1016/j.celrep.2021.108954

Figure 1. Pipeline for denoising and demixing in vivo voltage imaging data.

Figure 1.

The denoising steps (blue) comprise a set of distinct corrections for the sources of statistical noise and systematic artifacts that can arise in vivo. The demixing steps (green) use action potentials to identify the cell footprints and the differing spatial profiles of in-focus versus out-of-focus sources to apportion subthreshold dynamics between cells and background.