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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Am J Hematol. 2020 Sep 23;95(11):1269–1279. doi: 10.1002/ajh.25941

FIGURE 2.

FIGURE 2

Zambian early childhood malaria cohort. We observed an interaction between CYB5R3c.350C > G genotypes (wildtype, heterozygote, hemizygote) and risk categories of G6PD A alleles on severe anemia (P = .017). We therefore stratified our analysis according to the presence or absence of G6PD risk categories. A, In G6PD wildtype children or heterozygotes for A alleles, CYB5R3c.350C > G offered protection against severe anemia (P = .030 after adjustment for the covariates mentioned in Figure 1). B, In hemizygotes or homozyogtes for G6PD A+ or G6PD A−, CYB5R3c.350C > G did not show protection from severe malarial anemia