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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Cell Gene Ther Insights. 2020 Nov 19;6(10):1489–1505. doi: 10.18609/cgti.2020.163

FIGURE 2. Generating custom minimized DNA vector shapes.

FIGURE 2

(A) Schematic representation of the predicted effect of adding bend sites. Bend sites (red) are flexible, which should localize them to superhelical apices with supercoiling. (B) Representative image from the coarse-grained simulations showing the rod-shaped conformation, (the conformation observed most frequently with two bend sites), and summary of how frequently rod-shaped conformations were observed during the simulations, and of these rod-shaped conformations, what percent had the bend site(s) localized to the apices.