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. 2021 Apr 16;12:656541. doi: 10.3389/fimmu.2021.656541

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Copyright © 2021 Zhang, Dai, Wu, Wang, Cao, Zhang, Wang, Zhang and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic alterations in the two clusters. Frequency comparison according to types of mutation (A), SNV (B), INDEL and SNV (C) between the two clusters. (D) The Forest plot listing the top 17 most mutated genes between the two clusters. (E) Demonstration of the pathways involved in cancer biology in the two clusters. (F) The heatmap showing the concurrence or mutual exclusivity of the top 25 most mutated genes in the two clusters. *p < 0.05, *p < 0.01, ***P < 0.001, ****P < 0.0001. NS, not statistically significant.