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. 2007 Jul 4;17(4):347–353. doi: 10.1111/j.1750-3639.2007.00075.x

Figure 4.

Figure 4

Transport of Rh123 into membrane vesicles from LLC cells and LLC‐MDR1 cells and its inhibition by Aβ peptides. A. Membrane vesicles were incubated with 10 µM Rh123 in the presence of 4 mM ATP (▴) or 4 mM 5′‐AMP (▾). Vesicle‐associated fluorescence was determined by size‐exclusion centrifugation. B. Net ATP‐dependent transport into the vesicles from LLC‐MDR1 (▪) and from LLC (□) cells was calculated by subtracting values obtained in the presence of 5′‐AMP from those in the presence of ATP. C. ATP‐dependent transport (10 µM Rh123) in the presence of 5 µM Aβ1‐40 and Aβ1‐42 and 100 µM verapamil, respectively. Data represent means ± SD (n = 4). *Significant difference from control as determined by Student’s t‐test (P < 0.05).