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. 2008 Jan 31;18(2):240–252. doi: 10.1111/j.1750-3639.2008.00132.x

Figure 2.

Figure 2

(A) Insulin‐degrading enzyme (IDE) immunolabeling of neurons within the CA3‐4 and CA2 regions of the hippocampus in control cases and Alzheimer's disease (AD). (B) IDE immunolabeling of neurons is significantly reduced in AD cases (n = 20) compared with age‐matched controls (n = 22) (CA3‐4, P < 0.05 and CA2, P < 0.01). Reductions in IDE neuronal labeling in (C) CA3‐4 and (D) CA2 hippocampal regions are inversely related to Braak tangle stage, APOEε4 genotype, and Aβ plaque load in the temporal lobe. The error bars indicate standard error of mean.