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. 2007 Dec 18;18(2):225–238. doi: 10.1111/j.1750-3639.2007.00111.x

Figure 4.

Figure 4

BDNF receptors mRNA levels in the cortex and caudate of Huntington's disease (HD) subjects. TrkB, Trk‐T1 and T‐Shc mRNA levels were determined by means of quantitative real‐time polymerase chain reaction (PCR) in the cortex and caudate of eight controls and eight HD subjects. Trk mRNA was normalized to the level of GAPDH mRNA. The values are the averages ± SD of six independent PCR experiments. Control subjects, from left to right: 6182, 6142, 6002, 5959, 5936, 5919, 5074 and 5021; HD subjects, from left to right: 6051, 6121, 5570, 5576, 6010, 6183, 5507 and 6062. A. TrkB mRNA levels were significantly reduced in the caudate of the HD subjects (P < 0.01, Mann–Whitney two‐tailed test), but not in the cortex. The decreased levels did not correlate with disease grade (Spearman's test). B. The levels of Trk‐T1 mRNA were not significantly lower in the cortex or caudate of the HD subjects. C. T‐Shc mRNA levels were significantly increased in the cortex and caudate of the HD subjects (P < 0.05, Mann–Whitney two‐tailed test). A, B and C respectively show median TrkB, Trk‐T1 and T‐Shc mRNA levels in the control and HD subjects. The boundary of the box closest to zero indicates the 25th percentile, the line within the box marks the median, and the boundary of the box farthest from zero indicates the 75th percentile.