Table 2.
Expression of cyclin‐dependent kinase 5 (Cdk5), p‐Cdk5 and p35 in stroke patients demonstrated by Western blotting. Numbers show fold increase (control = 1.0): PI is peri‐infarcted and I is infarcted region; ND = not detected.
Patient no. | Survival (days) | Cdk5 | p35 | p‐Cdk5 | p25 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gray | White | Gray | White | Gray | White | Gray | White | ||||||||||
PI | I | PI | I | PI | I | PI | I | PI | I | PI | I | PI | I | PI | I | ||
1 | 2 | 2.8 | 3.1 | 0.3 | 2.2 | 4.2 | 3.4 | 2.3 | 3.3 | 0.4 | 0.4 | 1.0 | 1.0 | ND | ND | 1.8 | ND |
2 | 3 | 3.4 | 3.6 | 1.5 | 0.3 | 2.6 | 2.5 | 1.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 2.2 | 2.2 | 2.3 | ND |
3 | 3 | 1.5 | 1.6 | 1.5 | 3.7 | 1.0 | 1.0 | 1.0 | 1.0 | 4.2 | 4.3 | 3.0 | 2.6 | 1.9 | 2.0 | 1.9 | 2.0 |
4 | 5 | 0.3 | 1.5 | 1.5 | 1.7 | 1.0 | 1.0 | 1.0 | 1.5 | 2.3 | 2.1 | 2.6 | 2.5 | ND | ND | 1.8 | 1.8 |
5 | 5 | 1.5 | 0.5 | 2.3 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 2.4 | 1.0 | 1.0 | ND | ND | ND | ND |
6 | 6 | 0.4 | 1.5 | 2.7 | 2.5 | 1.0 | 0.3 | 1.0 | 1.0 | 1.5 | 3.1 | 1.0 | 2.8 | ND | ND | ND | ND |
7 | 9 | 1.5 | 2.8 | 0.5 | 1.0 | 1.0 | 0.3 | 1.0 | 1.0 | 1.0 | 1.7 | 1.0 | 3.6 | ND | ND | ND | ND |
8 | 14 | 0.5 | 0.5 | 0.5 | 0.5 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.5 | 2.9 | ND | 1.7 | ND | ND |
9 | 15 | 1.0 | 1.0 | 1.5 | 1.5 | 0.4 | 1.0 | 1.0 | 1.0 | 2.5 | 2.4 | 2.6 | 2.9 | ND | ND | 0.5 | 0.5 |
10 | 17 | 2.4 | 3.0 | 1.7 | 2.7 | 2.2 | 1.0 | 1.0 | 1.0 | 1.0 | 3.8 | 1.0 | 1.0 | ND | ND | ND | ND |
11 | 20 | 1.0 | 1.0 | 2.3 | 1.6 | 1.0 | 2.5 | 1.0 | 2.2 | 1.0 | 1.0 | 1.0 | 1.0 | ND | 1.7 | 1.8 | 1.8 |
12 | 26 | 2.3 | 0.3 | 1.5 | 1.5 | 1.0 | 0.3 | 1.0 | 1.0 | 1.0 | 2.4 | 1.0 | 3.9 | ND | ND | 1.8 | ND |
13 | 29 | 2.8 | 1.0 | 0.2 | 0.3 | 2.5 | 1.5 | 1.0 | 1.0 | 1.0 | 2.8 | 1.0 | 2.5 | ND | ND | ND | ND |
14 | 34 | 2.3 | 2.3 | 1.5 | 1.5 | 1.5 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 0.4 | 0.4 | 1.5 | 1.5 | ND | ND |
15 | 37 | 2.3 | 2.3 | 1.5 | 1.5 | 2.5 | 1.0 | 1.6 | 3.3 | 1.0 | 1.0 | 1.0 | 1.0 | ND | ND | ND | ND |
No. of patients | Increased | 10 | 9 | 11 | 10 | 6 | 4 | 3 | 4 | 4 | 9 | 4 | 8 | 3 | 5 | 6 | 3 |
Decreased | 3 | 3 | 4 | 3 | 1 | 3 | 0 | 3 | 2 | 2 | 2 | 2 | 0 | 0 | 1 | 1 | |
No change | 2 | 3 | 0 | 2 | 8 | 8 | 12 | 8 | 9 | 4 | 9 | 5 | 0 | 0 | 0 | 0 | |
Not detected | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 9 | 8 | 11 |