Figure 7.

Bioluminescent imaging of IOMM‐Lee xenografts, and their response to temozolomide (TMZ). Ten mice received injections of IOMM‐Lee‐Luc cells and were randomized into two groups that received either no treatment or treatment with 120 mg/kg TMZ for four consecutive days. A. Survival curves of athymic mice from control (dotted line) and TMZ‐treatment (solid line) groups are plotted. A significant survival benefit (P = 0.003) for mice treated with TMZ was observed. B. Luminescence readings for each mouse were normalized against its own day 10 luminescence reading. Normalized BLI plots associated with monitoring of intracranial tumor growth for control (black line) and TMZ‐treatment (gray line) groups are shown. C. Representative images from one control group mouse at the indicated time points post‐implantation of IOMM‐Lee‐Luc cells are shown.