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Figure 1.

Figure 1

Genotypes, proteotypes and phenotypes of FTLD. Clinical and pathological syndromes of FTD/FTLD constitute a clinicopathologic spectrum. The spectrum continues on the left with Alzheimer’s dementia‐frontal variant and on the right with ALS (*evident on both neuropathology and neuroimaging; ‡the inclusion proteopathy could be TDP‐43). AGD = argyrophilic grain disease; ALS = amyotrophic lateral sclerosis; CBD = corticobasal degeneration; FTD = frontotemporal dementia; FTLD = frontotemporal lobar degeneration; MND = motor neuron disease; PiD = Pick’s disease; PSP = progressive supranuclear palsy.