Table 2.
Immunohistochemical results in tissues of six cases of neuro‐invasive WNV infection. Abbreviations: CNS = central nervous system; ND = not done; NA = not applicable; WNV = West Nile virus.
| Organ | Case number | Summary | |||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | ||
| CNS | |||||||
| Neocortex | Positive | Negative | Negative | Negative | Negative | Negative | 1/6 |
| Hippocampus | Positive | Negative | Negative | Negative | ND | Positive | 2/5 |
| Thalamus | Positive | Positive | ND | Positive | ND | Positive | 4/4 |
| Basal ganglia | Positive | Positive | Negative | Negative | ND | Negative | 2/5 |
| Brainstem | Positive | Positive | Positive | Negative | Positive | Positive | 5/6 |
| Cerebellum | Positive | Positive | Positive | Negative | Positive | Positive | 5/6 |
| Spinal cord | Positive | ND | Positive | Positive | Positive | Positive | 5/5 |
| Kidney | |||||||
| Glomeruli | Negative | Negative | Negative | Negative | Negative | Negative | 0/6 |
| Tubules | Negative | Positive | Positive | Positive | Positive | Negative | 4/6 |
| Lung | |||||||
| Bronchi | Negative | Positive | Negative | Positive | Negative | Negative | 2/6 |
| Alveoli | Negative | Negative | Negative | Negative | Negative | Negative | 0/6 |
| Pancreas | |||||||
| Exocrine glands | Negative | Positive | Negative | Positive | Negative | Negative | 2/6 |
| Duct epithelia | Negative | Negative | Negative | Negative | Negative | Negative | 0/6 |
| Thyroid epithelia | ND | Positive | Negative | Positive | Negative | Negative | 2/5 |
| Intestinal epithelia | ND | Positive | Negative | Positive | Negative | ND | 2/4 |
| Prostate | ND | Positive | NA | ND | NA | ND | 1/1 |
| Testes | |||||||
| Epithelia | ND | Positive | NA | ND | NA | ND | 1/1 |
| Interstitial cells | ND | Negative | NA | ND | NA | ND | 0/1 |
| Skin | |||||||
| Epidermis | ND | Negative | ND | ND | Negative | ND | 0/2 |
| Eccrine glands | ND | Positive | ND | ND | Negative | ND | 1/2 |
| Liver hepatocytes | Negative | Negative | Negative | Negative | Negative | Negative | 0/6 |
| Bile duct epithelia | Negative | Positive | Negative | Negative | Negative | Negative | 1/6 |
| Spleen | |||||||
| Red pulp | Negative | Negative | ND | Negative | ND | Negative | 0/4 |
| White pulp | Negative | Negative | ND | Negative | ND | Negative | 0/4 |
| Lymph node | ND | Negative | ND | Negative | ND | Negative | 0/3 |
| Heart | Negative | Negative | Negative | Negative | Negative | Negative | 0/6 |
| Stomach | ND | Positive | ND | ND | Negative | ND | 1/2 |
| Esophagus | ND | ND | Positive | ND | ND | ND | 1/1 |
| Skeletal muscle | ND | Negative | ND | ND | Negative | ND | 0/2 |
| Bone | |||||||
| Osteocytes | ND | ND | ND | ND | Negative | Negative | 0/2 |
| Marrow | ND | ND | ND | ND | Negative | Negative | 0/2 |
| Peripheral nerves | Negative | Negative | ND | Negative | ND | ND | 0/3 |
| Blood vessels | Negative | Negative | Negative | Negative | Negative | Negative | 0/6 |
| Adipose tissue | Negative | Negative | Negative | Negative | Negative | Negative | 0/6 |
| Adrenal gland | ND | Negative | Negative | Negative | Negative | ND | 0/4 |
Positive, many WNV immunoreactive cells with complete filling of cytoplasm present; Negative, no WNV immunoreactive cells with complete filling of cytoplasm present.