Table 6.

Histopathological/molecular classification of medulloblastoma and outcome relative to the standard‐risk classic variant.

Good prognosis tumours:

Medulloblastoma with extensive nodularity

Nodular/desmoplastic medulloblastoma—particularly infantile

Medulloblastoma with β‐catenin nuclear immunoreactivity—mainly classic variant

Poor prognosis tumours:

Medulloblastoma with metastatic disease at presentation

Large cell/anaplastic medulloblastoma

Medulloblastoma with loss of chromosome 17p—often classic variant

Medulloblastoma with high frequency MYCC or MYCN amplification—often LC/A variant