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. 2008 Mar 27;18(3):401–414. doi: 10.1111/j.1750-3639.2008.00139.x

Figure 1.

Figure 1

Dexamethasone reduces the growth of malignant gliomas in mice without increasing survival. A. Representative section of a glioma stained with thionin from a mouse killed 20 days after implantation of GL261 cells into the right caudoputamen. Scale bar, 1 mm. B. Stereological analysis revealed a 33% decrease in glioma volume in mice injected twice daily with 1 mg/kg dexamethasone (Dex) compared with sham‐treated mice. *Student's t‐test, P = 0.0008. Data show the mean ± SE. C. Kaplan–Meier curves showing no difference in the probability of survival between glioma‐bearing mice treated or not with dexamethasone (n = 13 per group). Log‐rank test, P = 0.68. D. A chronic reduction in body weight was recorded in glioma‐bearing mice treated with dexamethasone (n = 13 per group). *MANOVA with repeated measures (P < 0.0001) followed by Student's t‐tests (P < 0.02). The data show mean changes in body weight from the day of tumor implantation.