Table 2.
Demyelination in the cerebellar cortex and white matter in multiple sclerosis (MS) and controls.
| Number of cases | % DM cortex | Range | % DM WM | Range | |
|---|---|---|---|---|---|
| AMS | 5 | 0 | 0–2.2 | 9.4 | 0–33.4 |
| RRMS | 3 | 2.8 | 0–7.5 | 1.0 | 0–3.1 |
| SPMS | 19 | 38.2 | 2.4–92.0 | 8.8 | 0–55.9 |
| PPMS | 10 | 26.5 | 0–86.7 | 2.6 | 0–28.4 |
| UPMS | 3 | 44.6 | 7.6–80.4 | 32.0 | 28.8–39.2 |
| Normal controls | 8 | 0 | 0 | ||
| Diff. hypoxia acute | 7 | 0 | 0 | ||
| Diff. hypoxia chronic | 13 | 0 | 0 | ||
| Focal hypoxia acute | 5 | 0 | 0 | ||
| Focal hypoxia chronic | 9 | 0 | 0 | ||
| Global | P < 0.005 | P < 0.05 | |||
| Ac&RR/Progressive | P < 0.001 | NS | |||
| SPMS/PPMS | NS | NS |
The values given in the table represent the median percentage and the range.
% DM cortex: percentage of cortical area which is demyelinated. % DM WM: percentage of white matter area which is demyelinated. Diff. hypoxia: diffuse hypoxic damage of the cerebellum.
Statistics: Global: global group differences between MS subgroups and controls; Ac&RR/PP and SP: differences between acute and relapsing vs. secondary and primary progressive MS patients; SPMS/PPMS: differences between secondary and primary progressive MS patients; Diff. hypoxia: global hypoxic/ischemic brain damage; acute: <1 week; chronic: >1 month; Focal hypoxia: focal infarct affecting the cortex.
Abbreviations: AMS = acute MS; RRMS = relapsing/remitting MS; SPMS = secondary progressive MS; PPMS = primary progressive MS; NS = not significant.