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. 2007 Feb 26;17(1):63–73. doi: 10.1111/j.1750-3639.2007.00052.x

Figure 1.

Figure 1

Schematic representation of the Tau gene and the six tau isoforms expressed in adult human brain. A. The human Tau gene contains 16 exons, of which exons 2, 3 and 10 (dark gray boxes) are alternatively spliced. Exons 4A, 6 and 8 (light gray boxes) are not transcribed in human brain. B. Six tau isoforms are generated by alternative mRNA splicing of exons 2, 3 and 10 (dark gray boxes). They range from 352 to 441 amino acids in length. The black boxes represent the microtubule‐binding repeats of tau.