Table 2.

Clinicopathologic data of subjects used for hypocretin brain tissue measurement. Abbreviations: Grade = Vonsattel et al's grade; CAG = CAG repeat length; Hcrt‐1 = hypocretin‐1; HD = Huntington disease; N.A. = not available.

	Subject no.	Age at death	Sex	Grade	CAG	Cause of death	Hcrt‐1 tissue content (pg/g)
Infantile HD	1*	19	F	3	86	Cachexia	1097
Adult HD	2	34	M	3	52	Unknown	389
	3	40	F	3	41	Suicide	530
	4	44	M	N.A.	50	Pneumonia	343
	5	45	M	4	53	Recurrent aspiration pneumonia	198
	6	49	M	3	47	Respiratory insufficiency	743
	7	51	M	3	46	Bronchopneumonia	360
	8	51	M	3	45	Unknown	584
	9	53	F	2	47	Pulmonary embolism	511
	10	54	M	3	43	Pneumonia	198
	11	55	F	3	47	Metastasized Grawitz tumor	617
	12	57	F	3	43	Pulmonary embolism	278
	13	57	M	4	49	Bronchopneumonia	275
	14	57	M	3	47	Unknown	665
	15	63	F	3	43	Basilar artery thrombosis	1066
	16	66	F	3	41	Squamous cell lung carcinoma	443
	17	69	F	2	42	Aspiration pneumonia	725
	18	75	M	3	43	Unknown	302
	19	77	M	3	39	Bronchopneumonia	376
Median		54.5		3.0	45.5		416.4
Percentiles (25th–75th)		48.0–63.8		2.5–3.0	42.8–47.5		295.8–629.4
Controls	1	37	M	—	—	Myocardial infarction	996
	2	46	M	—	—	Cardiac arhythmia	364
	3	48	M	—	—	Myocardial infarction	665
	4	52	M	—	—	Stroke	688
	5	60	F	—	—	Pneumonia	433
	6	63	F	—	—	Leptomeningeal metastasis	737
	7	64	M	—	—	Myocardial infarction	1368
	8	67	F	—	—	Aortic dissection	858
	9	68	M	—	—	Pneumonia	697
	10	70	M	—	—	Metastasized carcinoma	1282
	11	71	M	—	—	Cardiomyopathy	573
	12	74	M	—	—	Metastasized carcinoma	243
	13	76	M	—	—	Aortic dissection	638
	14	79	F	—	—	Stroke	892
	15	83	M	—	—	Leptomeningeal metastasis	358
	16	86	M	—	—	Myocardial infarction	570
Median		67.5					676.6
Percentiles (25th–75th)		54.0–75.5					467.5–883.9

^* This patient had juvenile HD and was therefore studied separately.