Table 3.
Neuronal inclusions in nuclei of HD hypothalami and adjacent regions. The last row indicates, per structure, the percentage of HD patients who had neuronal inclusions of the specified type. Abbreviations: Type = type of neuronal inclusions; C = cytoplasmic inclusions (ie, inclusions in dystrophic neurites); I = intranuclear inclusions; − = inclusions absent; + = inclusions present; SCN = suprachiasmatic nucleus; SON = supraoptic nucleus; PVN = paraventricular nucleus; INF = infundibular nucleus; DBB = diagonal band of Broca; NBM = nucleus basalis of Meynert; VMN = ventromedial nucleus; DMN = dorsomedial nucleus; LH = lateral hypothalamus; PFA = perifornical area; NTL = lateral tuberal nucleus; TMN = tuberomamillary nucleus; SMA = supramamillary area.
| Type | SCN | SON | PVN | DBB/NBM | INF | VMN | DMN | LH/PFA | NTL | TMN | SMA | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C | I | C | I | C | I | C | I | C | I | C | I | C | I | C | I | C | I | C | I | C | I | |
| HD‐1 | − | − | + | − | + | − | + | − | + | − | + | − | + | − | + | + | + | − | + | + | + | − |
| HD‐2 | − | − | − | − | − | − | + | − | + | + | + | − | + | − | + | + | + | − | + | − | + | − |
| HD‐3 | + | − | + | − | + | − | + | − | + | − | + | − | + | − | + | − | + | − | + | + | + | − |
| HD‐4 | − | − | − | − | + | − | + | − | + | − | + | − | + | − | + | − | − | − | + | + | + | − |
| HD‐5 | + | − | − | − | − | − | + | − | + | − | + | − | + | − | + | − | + | − | + | + | + | − |
| HD‐6 | − | − | − | − | + | − | + | − | + | − | + | − | + | − | + | − | − | − | + | − | + | − |
| HD‐7 | + | − | + | − | − | − | + | + | + | + | + | + | + | − | + | − | + | + | + | + | + | − |
| HD‐8 | + | − | + | − | + | − | + | + | + | − | + | − | + | − | + | − | + | − | + | + | + | − |
| % patients | 50 | 0 | 50 | 0 | 63 | 0 | 100 | 25 | 100 | 25 | 100 | 13 | 100 | 0 | 100 | 25 | 75 | 13 | 100 | 75 | 100 | 0 |