Table 4.
Spearman's ρ correlations (P‐values) between post‐mortem findings and other (clinical) disease parameters in the Huntington disease patients. The only significant correlation was between the prefrontal cortex hypocretin‐1 (Hcrt‐1) levels and Vonsattel et al's grade of neuropathologic disease severity. Trends were visible for the relations between Hcrt‐1 cell number and age of onset and between melanin‐concentrating hormone (MCH) cell number and disease duration. Abbreviation: CSF = cerebrospinal fluid.
| Age at death | Age of onset | Disease duration | Grade | CAG repeat no. | |
|---|---|---|---|---|---|
| Hcrt‐1 cell no. | 0.452 (0.260) | 0.643 (0.086) | −0.096 (0.820) | −0.482 (0.227) | −0.429 (0.337) |
| MCH cell no. | −0.500 (0.391) | −0.200 (0.747) | −0.821 (0.089) | −0.700 (0.188) | 0.300 (0.624) |
| Ventricular CSF Hcrt‐1 levels | −0.607 (0.148) | −0.607 (0.148) | −0.436 (0.328) | −0.090 (0.848) | 0.571 (0.180) |
| Prefrontal cortex Hcrt‐1 levels | 0.078 (0.760) | −0.417 (0.265) | 0.192 (0.620) | −0.666 (0.004)* | −0.179 (0.476) |
*
Correlation is significant at the 0.01 level.