Table 2.
Adenosine receptors mediated Adenylyl cyclase activity in Alzheimer's disease (AD).
| Adenylyl cyclase activity | ||||
|---|---|---|---|---|
| A1‐mediated (% of inhibition of Fsk‐stimulated) | A2‐mediated (% of basal) | |||
| Control | 23.3 ± 6.0 | (8) | 179.1 ± 18.9 | (8) |
| AD | 40.1 ± 3.3 | (11)* | 253.7 ± 35.7 | (9)* |
Inhibitory effect of N6‐cyclohexyladenosine, selective A1 receptor agonist, on Forkolin‐stimulated adenylyl cyclase (AC), and stimulatory effect of CGS21680, selective A2A receptor agonist, on basal AC were analyzed in samples from frontal cortex of AD as compared with control. Data are means ± SEM of experiments performed in triplicate with membrane preparations from different cases. *P < 0.05 significantly different from control value.