Figure 3.

Summary of the pathological changes observed in Alzheimer's disease (AD) after Aβ42 immunization. AD pathology is characterized by the presence of Aβ plaques, dystrophic neurites, intraneuronal tangles and neuropil threads with activated microglia and cerebral amyloid angiopathy, as illustrated with modified Bielschowsky staining and in diagrammatic form (A). After Aβ42 immunization, the Aβ plaques and dystrophic neurites are removed, microglia have phagocytosed Aβ, Aβ is increased in the vasculature and the neuropil threads and tangles are still observed (B). Scale bar = 50 µm.