Table 2.
Summary of aCGH defined losses gains and amplifications seen in the J‐series of medulloblastomas. Tumors which were used for the gene expression analysis are shown in bold in the left column. *Represents high amplitude single BAC events.******No detectable CNA.
| Sample ID | Small segments | Whole Chr | Amplification | Homozygous deletion | ||
|---|---|---|---|---|---|---|
| Gains | Losses | Gains | Losses | |||
| J1001 | Chr1:107834401‐qter, Chr10:39194926‐42197692 | Chr1:pter‐109185984 | Chr8, Chr13 | Chr2, Chr4, Chr10, Chr11, Chr15, Chr16, Chr21 | ****** | ****** |
| J1002 | ****** | ****** | Chr7, Chr8, Chr9, Chr19 | ****** | Chr4:131221437‐133802360* | ****** |
| J1004 | Chr1:120244511‐qter, Chr12:pter‐34591844 | Chr16:46266316‐qter | Chr8 | ****** | ****** | ****** |
| J1005 | Chr4:752619‐12411625, Chr9:pter‐68203104 | Chr5:16968719‐17806053, Chr9:67566555‐qter, Chr15:90029599‐96519678 | Chr2 | ****** | ****** | ****** |
| J1006 | ****** | Chr8:pter‐28762956, Chr8:61769195‐102107868 | Chr7, Chr17 | ****** | ****** | ****** |
| J1007 | Chr7:pter‐78192971 | Chr8:109441448‐123818629, Chr14:36467869‐43823109 | Chr19 | ****** | ****** | ****** |
| J1008 | Chr1:pter‐50462496, Chr3:136692885‐152413314, Chr9:100327175‐120005880, Chr13:40876134‐46118238, ChrX:43382420‐50860186 | Chr2:193194019‐qter, Chr4:73511981‐qter, Chr6:56381084‐qter, Chr11:pter‐48644474, Chr17:pter‐11132723, Chr18:15367893‐qter, Chr19:50275933‐60725260, ChrX:4032843‐44358192, ChrX:49063091‐154186476 | Chr7, Chr9, Chr19 | ****** | Chr2:9029875‐16529264, Chr2:115093327‐146734712, Chr2:191120018‐195293720, Chr11:67942137‐70756232, Chr11:97534216‐101562543, Chr12:pter‐18599946, Chr12:22210386‐36142961, Chr12:33534861‐42459838, Chr12:53208104‐60917552, Chr12:75456697‐81285086, Chr12:88253032‐89158341, Chr17:9904704‐19626362 | ****** |
| J1010 | Chr17:15223450‐qter | ****** | Chr7 | ****** | ****** | ****** |
| J1012 | ****** | Chr8:7328299‐8837121 | Chr3 | Chr10 | ****** | ****** |
| J1014 | Chr17:21191548‐qter | Chr1:pter‐48215170, Chr17:pter‐22127985 | Chr5, Chr6, Chr9, Chr18, Chr22 | Chr8, Chr10 | ****** | ****** |
| J1016 | Chr2:pter‐16529264, Chr3:59779777‐65182251, Chr10:pter‐30639661, Chr11:pter‐66379947, Chr13:98923852‐103089594, Chr17:15362704‐qter, Chr18:16773951‐qter | Chr1:pter‐8902538, Chr4:48839424‐120282908, Chr8:pter‐39846706, Chr10:30613638‐qter, Chr11:65980427‐qter, Chr12:33076084‐119020229, Chr16:46266316‐qter, Chr17:pter‐15511681, Chr18:pter‐16840697 | Chr7, Chr12 | ****** | ****** | ****** |
| J1019 | ****** | ****** | ****** | ****** | ****** | ****** |
| J1020 | Chr1:148810010‐qter, Chr17:19800213‐78206787 | Chr4:170218065‐qter, Chr8:126626507‐128612329, Chr10:133471230‐qter, Chr17:pter‐19744530, Chr19:pter‐10248852 | Chr18, Chr21 | Chr3, Chr13 | Chr8:127751581‐129784458 | ****** |
| J1021 | Chr9:pter‐68203104, Chr16:31443695‐34476094, Chr21:15043867‐18244635 | Chr1:221304577‐224587821, Chr2:163059060‐183645799, Chr3:pter‐94987544, Chr9:67566555‐qter, Chr11:pter‐48644474 | ****** | Chr19 | Chr1:39046537‐40431821, Chr11:56507045‐58480720 | Chr11:10692195‐13338428 |
| J1022 | Chr6:pter‐61963054, Chr12:97700309‐qter, Chr17:17349840‐qter, Chr20:35152344‐qter, Chr22:14466338‐26007486 | Chr2:40597715‐qter, Chr3:89771786‐qter, Chr5:127176867‐145274925, Chr16:46266316‐qter, Chr17:pter‐16616643, Chr18:73111607‐qter, Chr22:25865941‐qter | Chr4, Chr5, Chr7, Chr13 | Chr9, Chr11 | ****** | ****** |
| J1023 | Chr17:18318880‐qter | Chr17:pter‐19626362 | Chr4 | ****** | Chr2:15242057‐19899402, Chr19:62624158‐qter* | ****** |
| J1024 | Chr17:17349840‐qter | Chr16:53324475‐qter, Chr17:pter‐16616643 | Chr5, Chr7, Chr18 | Chr8, Chr10, Chr20 | Chr2:15242057‐16529264 | ****** |
| J1025 | ****** | ****** | Chr11 | ****** | ****** | Chr4:186788298‐186991592 |
| J1026 | Chr17:15362704‐qter | Chr17:pter‐15511681 | ****** | ****** | ****** | ****** |
| J1067 | Chr21:9954111‐29260484 | Chr3:104771763‐qter, Chr6:pter‐44649064, Chr19:42180358‐qter | Chr4, Chr8, Chr14 | Chr2, Chr5, Chr10, Chr11, Chr16 | ****** | ****** |
| J1115 | Chr2:pter‐24531246, Chr2:32910747‐54121420, Chr6:111424176‐qter, Chr8:pter9‐8837121, Chr15:43812588‐qter, Chr17:17349840‐qter, Chr18:3822165‐11582119, Chr21:9954111‐17336775 | Chr1:pter‐33790776, Chr4:pter‐4538586, Chr5:173821419‐qter, Chr7:pter‐7114750, Chr7:55381999‐76132954, Chr7:96323599‐102435956, Chr9:125854825‐qter, Chr11:pter‐47989032, Chr16:266993‐qter, Chr17:pter‐8338030 | ****** | Chr16, Chr19, Chr20 | ****** | ****** |
| J319 | Chr6:109463437‐qter, Chr15:41935933‐qter, Chr17:17349840‐qter | Chr11:pter‐47277667, Chr16:50943879‐qter | ****** | ****** | ****** | ****** |