Table 1.
Age | Mutation | Muscle | Myonuclei/fibers merging into the tendon | Myonuclei disintegrating* | Myofibers degenerating† |
---|---|---|---|---|---|
5 weeks | LMNA−/− | Rectus femoris‡ | 75/50 | 17/50 | 12/50 |
Soleus§ | 28/20 | 18/50 | 10/20 | ||
7 weeks | LMNA−/− | Rectus femoris | 91/50 | 15/50 | 10/50 |
Soleus | 13/20 | 13/50 | 7/20 | ||
7 weeks | LMNA−/− | Rectus femoris | 117/50 | 21/50 | 11/50 |
Soleus | 36/20 | 12/50 | 14/20 | ||
7 weeks | LMNA−/− | Rectus femoris | 82/50 | 21/50 | 13/50 |
Soleus | 31/20 | 19/50 | 5/20 | ||
7 weeks | LMNA−/− | Rectus femoris | 79/50 | 12/50 | 5/50 |
Soleus | 22/20 | 13/50 | 10/20 | ||
5 weeks | LMNA+/+ | Rectus femoris | 27/50 | 0/50 | 0¶ |
Soleus | 8/20 | 0/50 | 0¶ | ||
6 months | LMNA+/+ | Rectus femoris | 19/50 | 0/50 | 0¶ |
Soleus | 5/20 | 0/50 | 0¶ |
Number of disintegrating myonuclei per 50 nuclei counted.
†Number of degenerating myofibers per 50 (rectus femoris muscle) and 20 (soleus muscle) fibers counted, respectively.
‡Of a total of 50 fibers per muscle.
§Of a total of 20 fibers per muscle.
¶Number of degenerating myofibers across the whole section.