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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Cardiol Plus. 2020 Sep 30;5(3):101–108. doi: 10.4103/cp.cp_17_20

Figure 2:

Figure 2:

Aldehyde dehydrogenase 2ALDH2 is required for the bioactivation of nitroglycerin. The release of nitric oxide (NO) from nitroglycerin, or glyceryl trinitrate (GTN), requires ALDH2 (Left). NO activates soluble guanylate cyclase to form cyclic guanosine monophosphate and produce vasodilation. There is negative feedback from NO to inhibit ALDH2 activity. The ALDH2*2 variant decreases the vasodilatory response of nitroglycerin compared to wild-type since it is unable to bioactivate GTN and release NO (Right).