Table 3.

Positive and negative predictive values of FDDNP labeling for birefringence. Abbreviations: GNFT = globose neurofibrillary tangle; PiB = Pick body; GCI = glial cytoplasmic inclusion; VH = vascular hyaline; cSP = classic senile plaque; LB = Lewy body; CLB = cortical Lewy body; NFT = neurofibrillary tangle; nSP = neuritic senile plaques; PP = prion plaque; PPP = primitive prion plaque; VA = vascular amyloid; NA, not applicable.

Histological structure	cSP	nSP	NFT	VA	PP	PPP	GNFT	PiB	LB	CLB	GCI	VH
Positive predictive value	1.0	0.50	0.71	0.86	0.88	0.40	NA†	NA†	0.87	0.09	NA†	NA†
Negative predictive value	NA*	0.75	0.39	0.57	0.47	0.94	0.06	0.99	1.0	1.0	1.0	1.0

^* FDDNP labeled all cSPs, therefore negative prediction value of FDDNP labeling can not be calculated.

^† FDDNP did not detectably label any of GNFTs, PiBs, GCIs or VH, therefore positive prediction value of FDDNP labeling can not be calculated.