Table 4. Clinical symptoms between patients with Helicobacter pylori (HP) negative and successful HP eradication groups.

	HP negative (n = 18)	HP positive at baseline (n = 17)
		Pre-HP eradication	pa	Post-HP eradication	pa
Total TWOQ-9 score	4.7 ± 2.0	6.0 ± 1.3	0.028	4.4 ± 1.7	0.625
Total GI symptom score	15.4 ± 8.1	12.8 ± 7.3	0.335	8.1 ± 4.5	0.003
• Heartburn	2.4 ± 2.8	1.2 ± 2.8	0.211	0.6 ± 1.4	0.024
• Bloating	3.3 ± 2.7	2.9 ± 3.2	0.740	1.1 ± 1.6	0.007
• Nausea	0.6 ± 1.5	0.2 ± 0.5	0.267	0.2 ± 0.5	0.267
• Vomiting	0.1 ± 0.5	0.1 ± 0.5	0.968	0.1 ± 0.5	0.968
• Abdominal pain	1.6 ± 2.5	1.8 ± 2.6	0.760	0.9 ± 2.2	0.404
• Diarrhea	0.5 ± 1.2	0.4 ± 1.1	0.819	0.0 ± 0.0	0.096
• Constipation	6.9 ± 3.5	6.2 ± 3.5	0.516	5.2 ± 2.8	0.115
Total NMSQ score	37.9 ± 20.9	33.4 ± 13.3	0.544	29.3 ± 14.1	0.173
• Dysphagia	1.3 ± 1.3	0.7 ± 1.0	0.124	0.3 ± 0.6	0.008
PDQ-8 score	9.2 ± 6.8	10.9 ± 5.3	0.409	8.6 ± 5.2	0.759
‘Off’ UPDRS motor score	29.8 ± 14.8	29.9 ± 9.6	0.740	26.0 ± 10.0	0.388
‘On’ UPDRS motor score	15.1 ± 11.3	12.7 ± 7.0	0.618	10.6 ± 5.0	0.146
Time up and go (sec)	12.1 ± 6.3	11.8 ± 8.5	0.817	9.8 ±2.8	0.289
L-Dopa onset time (min)	15.4 ± 10.0	21.2 ± 6.9	0.041	19.5 ± 9.6	0.229
L-Dopa peak time (min)	34.5 ± 10.5	35.7 ± 7.9	0.669	34.9 ± 13.8	0.979
Daily ‘on’ time (h)	12.0 ± 2.4	10.9 ± 1.9	0.140	11.8 ± 2.0	0.781
Daily ‘off’ time (h)	3.9 ± 2.2	4.7 ± 1.5	0.181	4.0 ± 2.1	0.819
Dyskinesia (h)	1.5 ± 2.3	1.1 ± 1.6	0.630	1.3 ± 1.8	0.802

^a Compared to HP negative group.

TWOQ-9: Thai version of the 9-item Wearing-off Questionnaire; GI: Gastrointestinal; NMSQ: Non-Motor Symptoms Questionnaire; PDQ: Parkinson’s Disease Questionnaire; UPDRS: Unified Parkinson’s Disease Rating Scale; L-Dopa: Levodopa.

Statistically significant p-values are in bold.