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. 2021 May 4;16(5):e0251071. doi: 10.1371/journal.pone.0251071

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© 2021 Joyce et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — Comparison of the wildtype (A) and altered protein (B). Using PredictProtein reveal that the two proteins are expected to differ throughout with regards to secondary structure, protein binding and conservation. In addition, modelling of both proteins using Swiss-Model (C) reveal that in the altered molecule, the 15 amino acids at the C-terminus, involved in the shifted reading frame, do not align with the N-terminus (white and red in C) of the wildtype protein at all, and also do not align with any other known protein structures.