Table 1. Predicted pathogenicity.
| Amino acid change | PolyPhen Result | PolyPhen Score | Provean Result | Provean Score (Threshold <-2.5) |
|---|---|---|---|---|
| M114H | Possibly Damaging | 0.566 | Neutral | -0.102 |
| R115E | Possibly Damaging | 0.462 | Neutral | -0.647 |
| L116A | Possibly Damaging | 0.816 | Deleterious | -3.109 |
| T117H | Probably Damaging | 0.974 | Deleterious | -3.353 |
| A118R | Probably Damaging | 0.958 | Neutral | -1.118 |
| T119H | Probably Damaging | 0.974 | Neutral | -1.647 |
| Y120L | Possibly Damaging | 0.816 | Deleterious | -8 |
| R121P | Possibly Damaging | 0.827 | Deleterious | -4.941 |
| Y122V | Possibly Damaging | 0.816 | Deleterious | -6.235 |
| I123H | Possibly Damaging | 0.944 | Deleterious | -6.882 |
| L124P | Probably Damaging | 0.974 | Neutral | -1.588 |
| S125L | Possibly Damaging | 0.633 | Deleterious | -3.176 |
| C126L | Possibly Damaging | 0.462 | Deleterious | -10 |
| H127S | Possibly Damaging | 0.462 | Neutral | 2.255 |
| C128L | Possibly Damaging | 0.462 | Deleterious | -7.118 |