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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: ACS Infect Dis. 2021 Jan 20;7(2):461–470. doi: 10.1021/acsinfecdis.0c00809

Figure 1.

Figure 1.

PBPs and LDTs catalyze transpeptidase reactions between different amino acid substrates. A subset of PBPs is called d,d-transpeptidases (DDTs), and they cross-link a position 4 d-Ala to a neighboring mDAP residue. Mtb also uses l,d-transpeptidases (LDTs), which form 3 → 3 cross-links (mDAP to mDAP). The DDT protein depicted in dark gray (left) is PonA1 (PDB ID: 5CXW) and the LDT structure (right) is LdtMt2 (PDB ID: 5K69). (Dark gray hexagon) MurNAc, N-acetylmuramic acid; (Light gray hexagon) GlcNAc, N-acetylglucosamine; l-Ala, l-alanine; d-iGln, d-isoglutamine; mDAP, meso-diaminopimelic acid; d-Ala, d-alanine.