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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Microphysiol Syst. 2018 Oct 16;2:7. doi: 10.21037/mps.2018.09.01

Figure 5.

Figure 5

Human gut-on-a-chip used as an intestinal inflammation model. (A) Assessment of the intestinal villi integrity in the presence of commensal bacteria, pathogenic bacteria, and endotoxin, with or without immune cells. (B) Assessment of the intestinal villi integrity in the presence of probiotic bacteria alone and combined with pathogenic bacteria, immune cells, and antibiotics. (C) Cytokine secretion profile of inflammatory of endothelial cells challenged with LPS in the presence of immune cells. (D) Intestinal villi injury caused by proinflammatory cytokines and the neutralizing effect of anti IL-8 monoclonal antibody. (E) Bacterial overgrowth effect caused by the cessation of peristalsis-like stimulation. Scale bars, 50 μm. Taken from reference (68).